The size reduction performance of a pneumatically driven single-vessel pharmaceutical processor is described. Two materials were considered, namely commercially available granular lactose (CAGL) and high-speed mixer granulator lactose (HSMGL). In both cases there is an initial phase in which the particle diameter is reduced rapidly. The rate at which the size reduction decreases is reduced with time. The final particle diameter was found to be dependent on the material being processed. In the case of CAGL, the minimum size achieved was 150 μm, while in the case of the HSMGL the final particle diameter was 100 μm.
AultonM. E. (Ed.) PharmaceuticsâThe Science of Dosage Form Design, 1988, Chs 32, 34, 37 and 38 (Churchill Livingstone).
2.
MacGregorS. A.StaniforthJ. N.NewnesL. B.KayG. R.A preliminary study of a single-vessel pharmaceutical processor. Proc. Instn Mech. Engrs, Part E, Journal of Process Mechanical Engineering, 1996, 210(E2), 121–124.
3.
RobinP.LucisanoR. P.PearlswigD. M.Rationale for selection of a single-pot manufacturing process using microwave/vacuum drying. Pharmaceut. Technol., 1994, 18(5), 28 et seq.
4.
KayG. R.StaniforthJ. N.TobynM. J.HorrillM. D.NewnesL. B.MacGregorS. A.LiM.AthertonG.LammingR. C.HajeeD. W.Design of a fluid energy single vessel powder processor for pharmaceutical use. Int. J. Pharmaceut., 1999, 181(2), 243â254.
5.
KayG. R.Design and characterisation of a single vessel pharmaceutical processor. MPhil thesis, Department of Pharmacy and Pharmacology, University of Bath, 1997.
