The effects of different anaesthetic agents on the estimation of uterine vascular permeability in mice

Vascular permeability in the uterus and other tissues of mice was assessed using the accumulation of ¹²⁵I-human serum albumin 30 min after its intravenous injection. The anaesthetic agent employed for the ¹²⁵I-albumin injection differentially affected the estimates of vascular permeability: intraperitoneal (i.p.) tribromoethanol of pentobarbitone sodium produced significantly higher values for the uterus and body wall than ether. The i.p. administration of either Saffan or pentobarbitone sodium reduced estimates of vascular permeability in the duodenum. These results emphasize the importance of the choosing a suitable anaesthetic agent in vascular studies of the uterus and other abdominal tissues.