Abstract
Since the original publications on the relation between thrombophilias and adverse pregnancy outcome in the mid-1990s, more and more obstetricians and gynaecologists started to use heparin and/or low-molecular weight heparin (LMWH) empirically for secondary prevention of late pregnancy complications and the prevention of miscarriages in couples presenting with recurrent pregnancy loss.
In the absence of good evidence, it is not surprising to see ongoing, often heated, debates between ‘believers’ and ‘sceptics’. With regard to the use of LMWH in patients with recurrent spontaneous miscarriages (RSM), the two recent publications by Kaandorp et al. (N Engl J Med 2010) and Clark et al (Blood 2010) have at least filled one gap in our evidence base to manage couples presenting with RSM patients.