Safety Concerns Involving Transdermal Patches and Magnetic Resonance Imaging (MRI)

Transdermal drug delivery systems have become more prevalent since their initial introduction in the 1980s. Recently, safety concerns have arisen regarding the continued application of transdermal patches during magnetic resonance imaging (MRI) procedures. Case reports have revealed that serious burns may occur in patients undergoing MRI who have transdermal patches with metallic content applied to their skin. The metallic component of these patches acts as a conductor for the radiofrequency pulses of the MRI, inducing an electric current and thereby resulting in intense heat and burns. Currently, over 20 brand and generic transdermal drug delivery systems are available. Not all available patches contain metallic components that necessitate removal prior to MRI. This review provides information related to the metallic content of available transdermal patches and also provides recommendations regarding reapplication of transdermal therapy after a scan. Health care professionals should be aware that published information regarding transdermal therapy and risk of burns appears to vary from source to source as the primary reference for such information is verbal communication with manufacturers. Given this issue, it may be often easier to err on the side of caution and remove the patch prior to MRI.