Low-Molecular-Weight Heparins in the Treatment of Pulmonary Embolism

Anderson FA Wheeler HB . Venous thromboembolism: Risk factors and prophylaxis. Clin Chest Med 1995;16:235–50.

Anderson FA Wheeler HB Goldberg RJ Hosmer DW Patwardham NA Jovanovic B A population-based perspective of the hospital incidence and case—fatality rate of deep vein thrombosis and pulmonary embolism. The Wochester DVT study. Arch Intern Med 1991;151:933–8.

Clagett GP Anderson FA Heit J Levine MN Wheeler HB . Prevention of thromboembolism. In: Dalen JE Hirsh J , eds. Fourth ACCP Consensus Conference on Antithrombotic Therapy. Chest 1995;108(suppl):321S–34S.

Hirsh J Levine MN . Low molecular weight heparin. Blood 1992;79:1–17.

Levine M Gent M Hirsh J Leclerc J Anderson D Weitz J A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N Engl J Med 1996;334:677–81.

Leizorovicz A Simonneau G Decousus H Boissel JP . Comparison of efficacy and safety of low molecular weight heparins and unfractionated heparin in initial treatment of deep venous thrombosis: A meta-analysis. BMJ 1994;309:299–304.

Lensing A Prins MH Davidson BL Hirsh J . Treatment of deep venous thrombosis with low-molecular-weight heparins: A meta analysis. Arch Intern Med 1995;155:601–7.

Koopman MMW Prandoni P Piovella F Ockelford PA Brandjes DPM Van Der Meer J Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. N Engl J Med 1996;334:682–7.

Quilliet L Charbonnier B Delahousse B Gruel Y Brochier ML Leroy J Traitement des embolies pulmonaires aiguës par une héparine de bas poids moléculaire par voie intraveineuse. Recherche de la posologie optimale. Arch Mal Cœur 1988;81:1219–25.

Toulemonde F . Is the problem of the international standard for low molecular weight heparin crucial for the clinician? Haemostasis 1990;20:119–23.

Albada J Nieuwenhuis HK Sixma JJ . Treatment of acute venous thromboembolism with low molecular weight heparin (Fragmin): Results of a double-blind randomized study. Circulation 1989;80:935–40.

Meyer G Brenot F Pacouret G Simonneau G Juvin KG Charbonnier B Subcutaneous low-molecular-weight heparin Fragmin versus intravenous unfractionated heparin in the treatment of acute non massive pulmonary embolism: An open randomized pilot study. Thromb Haemostas 1995;74:1432–5.

Brenot F Gillet-Juvin K Pacouret G Charbonnier B Sors H Guernic JL Subcutaneous low molecular weight heparin (Fragmin) versus intravenous unfractionated heparin in the treatment of acute non massive pulmonary embolism: An open pilot study (abstract). Thromb Res 1992; 65(suppl 1):S135.

Kuijer PMM Gallus AS Cade JF Büller HR . Randomized comparison of LMWH versus standard heparin in the initial treatment of pulmonary embolism (abstract). Thromb Haemostas 1995;73:974.

Partsch H Kechavarz B Mostbeck A Köhn H Lipp C . Frequency of pulmonary embolism in patients who have iliofemoral deep vein thrombosis and are treated with once- or twice-daily low-molecular-weight heparin. J Vasc Surg 1996;24:774–82.

Huet Y Gouault-Heilmann M Contant G Brun-Buisson C . Treatment of acute pulmonary embolism by a low molecular weight fraction. A preliminary study. Intensive Care Med 1987;13:126–30.

Huet Y Gouault-Heilmann M Brun-Buisson C Contant G Brun-Ney D . Low molecular weight heparin fractions as anticoagulant therapy in pulmonary embolism in man (abstract). Circulation 1984;70(suppl 2):96.

Huet Y Gouault-Heilmann M . Low molecular weight heparin fraction PK 10169: A new therapeutic means for anticoagulation therapy? Haemostasis 1986;16:165–72.

Huet Y Gouault-Heilmann M Parente T Brun-Buisson C . Subcutaneous enoxaparin as anticoagulation therapy in acute pulmonary embolism in man (abstract). Am Rev Respir Dis 1987;135:A353.

Théry C Simonneau G Meyer G Hélénon O Bridey F Armagnac C Randomized trial of subcutaneous low-molecular-weight heparin CY 216 (Fraxiparine) compared with intravenous unfractionated heparin in the curative treatment of submassive embolism. A dose-ranging study. Circulation 1992;85:1380–9.

Torbicki A Pacho R Jedrusik P Pruszeyk P . Noninvasive diagnosis and treatment of a saddle pulmonary embolism. Chest 1996;109:1124–6.

The Columbus Investigators. Low molecular weight heparin is an effective and safe treatment for deep-vein thrombosis and pulmonary embolism (abstract). Blood 1996;88(1 suppl pt I):626a.

The Columbus Investigators. Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. N Engl J Med 1997;337:657–62.

Pineo GF Hull RD Brant RF Elliott CG Raskob GE Feldstein W . Subcutaneous low-molecular-weight heparin (LMWH) compared with continuous intravenous heparin (IVH) in the treatment of pulmonary embolism (PE) (abstract). Annu Meeting Int Soc Technol Assessment 1995;11:21.

Simonneau G Sors H Charbonnier B Beau B . Once daily low molecular weight heparin (LMWH) tinzaparin versus unfractionated heparin (UFH) in the treatment of pulmonary embolism (PE) (abstract). Haemostasis 1996;26(suppl 3):006.

Simonneau G Sors H Charbonnier B Beau B . Once daily low molecular weight heparin tinzaparin versus unfractionated heparin in the treatment of pulmonary embolism (abstract). Am J Respir Crit Care Med 1997;155(suppl): A113.

Simonneau G Sors H Charbonnier B Page Y Laaban JP Azarian R A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. N Engl J Med 1997;337:663–9.