Characterization of Solution-Cast Extracts from Cardiothane-51 ® by FT-IR and ESCA

Abstract

Extracts from Cardiothane-51 ® have been cast from solvents of varying polarity. Cardiothane-51® can be described as block polyether-polyurethane copolymer with a 10% by weight addition of polydimethylsiloxane (DMS) that is partially copolymerized and partially blended to form a copolv mer/polv blend. FT-IR has been utilized to probe bulk and near-surface bonding and composition in the solution-cast extract films. Results show that Cardiothane-51 ® is similar in bulk composition, as measured by FT-IR, to Avcothane-51®. However, these two polymers are quite different in composition over a depth of microns. Both Cardiothane-51 ® and Avcothane-51 ® have surfaces, as measured by ESCA, which are dominated by their DMS component with a significant amount of the polyether present. Results suggest that the DMS in Cardiothane-51 ® is a blended phase, because of its ease of extraction.

Keywords

Molecular structure Reflectance spectroscopy Surface analysis Biomedical polymers

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References

Kambic

H. E.

Murabayashi

, and Nosé

, Chem. and Eng. News 64, 30 (1986).

Ward

R. S.

and Nyilas

, in New Developments in Organsilicon Polymers (Wiley, New York, 1978), p. 219.

Iwamoto

and Ohta

, Appl. Spectrosc, 38, 359 (1984).

Iwamoto

Ohta

Matsuda

, and Imachi

, J. Biomed. Mater. Res. 20, 507 (1986).

Gardella

J. A.

Jr. Grobe

G. L.

III Hopson

W. L.

, and Eyring

E. M.

, Anal. Chem. 56, 1169 (1984).

Grobe

G. L.

III Gardella

J. A.

Jr. Hopson

W. L.

McKenna

W. P.

, and Eyring

E. M.

, J. Biomed. Mater. Res. 21, 211 (1987).

Sung

C. S. P.

and Hu

C. B.

, J. Biomed. Mater. Res. 12, 791 (1978).

Sung

C. S. P.

and Hu

C. B.

, J. Biomed. Mater. Res. 13, 45 (1979).

Graham

S. W.

and Hercules

D. M.

, J. Biomed. Mater. Res. 15, 349 (1981).

10.

Thomas

H. R.

and O'Malley

J. J.

, in Photon, Electron, and Ion Probes of Polymer Structure and Properties, Dwight

D. W.

Fabish

T. J.

, and Thomas

H. R.

, Eds. (American Chemical Society, Washington, D.C., 1981), Vol. 162, p. 319.

11.

Schmitt

R. L.

Gardella

J. A.

Jr. Magill

J. H.

Salvati

, and Chin

R. L.

, Macromolecules 18, 2676 (1986).

12.

Schmitt

R. L.

Gardella

J. A.

Jr. , and Salvati

Jr. , Macromolecules, 19, 648 (1986).

13.

Clark

D. T.

and Dilks

, J. Poly. Sci. (Poly. Chem. Ed.) 14, 533 (1976).

14.

Thomas

H. R.

and O'Malley

J. J.

, Macromolecules 12, 323 (1979).

15.

Baier

R. E.

, in The Organization of Blood Component Near Interfaces, Ann. N.Y. Acad. Sci. (New York Academy of Science, New York, 1977), Vol. 17, p. 283.

16.

Boretos

J. W.

Pierce

W. S.

Baier

R. E.

Leror

A. F.

, and Donachy

H. J.

, J. Biomed. Mater. Res. 9, 327 (1975).

17.

Ratner

B. D.

, in Photon, Electron, and Ion Probes of Polymer Structure and Properties, Dwight

D. E.

Fabish

T. J.

, and Thomas

H. R.

, Eds. (American Chemical Society, Washington, D.C., 1981), Vol. 162, p. 371.

18.

Kambour

R. P.

, in Block Polymers, Aggarwall

S. L.

, Ed. (Plenum Press, New York, 1970), p. 263.

19.

Burrnell

, in The Polymer Handbook, Brandrup

and Immergut

E. H.

, Eds. (Wiley, New York, 1975), Section IV, p. 337.

20.

Grobe

G. L.

III Gardella

J. A.

Jr. Chin

, and Salvati

Jr. , Appl. Spectrosc. 42, 989 (1988).

21.

Bicking

M. K. L.

Kniseley

R. N.

, and Svec

H. J.

, Anal. Chem. 55, 200 (1983).

22.

Moulder

J. F.

Hammond

J. S.

, Research and Development, 21 (1984).

23.

Mirabella

P. M.

Jr. , J. Poly. Sci., Poly. Phys. Ed. 23, 861 (1985).

24.

Baier

R. E.

Meyer

A. E.

, and Fornalik

, personal communication.

25.

Gardella

J. A.

Jr. Graham

S. W.

, and Hercules

D. M.

, in Polymer Characterization, Craver

C. D.

, Ed. (American Chemistry Society, Washington, D.C., 1983), pp. 635–676.

26.

Ratner

B. D.

, Annals of Biomed. Eng. 11, 313 (1983).

27.

Grobe

G. L.

III Gardella

J. A.

Jr. , and Chin

R. L.

, “Surface Spectroscopic Studies of Solution Cast Biocompatible Polymeric Mixtures,” delivered at the 35th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Atlantic City (1984).