Cherubism is an autosomal-dominant syndrome characterized by bilateral maxillomandibular bony degeneration, fibrous connective tissue hyperplasia, and displacement of permanent tooth germs. Reossification of the cystic lumen occurs spontaneously, but dislocated teeth must be realigned orthodontically. Advancements in virtual 3D reconstruction of anatomic structures based on computed tomography (CT) or cone beam CT data have provided for more predictable individual treatment planning. We evaluated two software programs for making densitometry and volume measurements of cystic areas in the mandibles, and for 3D visualization of permanent tooth germs within the cystic lumen, in two siblings with cherubism.
BenettiC.CrippaR.MazzaM.BasettiE.Nonfamilial cherubism. A clinical case report.Minerva Stomatol.1995; 44: 119–126.
2.
BohmB.HirschfelderU.Localization of lower right molars in a panoramic radiograph, lateral cephalogram and dental CT.J Orofac Orthop.2000; 61: 237–245.
3.
CavalcantiM.G.RochaS.S.VannierM.W.Craniofacial measurements based on 3D-CT volume rendering: implications for clinical applications.Dentomaxillofac Radiol.2004; 33: 170–176.
4.
CavalcantiM.G.VannierM.W.The role of three-dimensional spiral computed tomography in oral metastases.Dentomaxillofac Radiol.1998a; 27: 203–208.
5.
CalvacantiM.G.VannierM.W.Quantitative analysis of spiral computed tomography for craniofacial clinical applications.Dentomaxillofac Radiol.1998b; 27: 344–350.
6.
Carvalho SilvaE.Carvalho SilvaG.C.VieiraT.C.Cherubism: clinico-radiographic features, treatment, and long-term follow-up of 8 cases.J Oral Maxillofac Surg.2007; 65: 517–522.
7.
CohnenM.KemperJ.MobesO.PawelzikJ.ModderU.Radiation dose in dental radiology.Eur Radiol.2002; 12: 634–637.
8.
De LangeJ.Van den AkkerH.P.Clinical and radiological features of central giant-cell lesions of the jaw.Oral Surg Oral Med Oral Pathol Oral Radiol Endod.2005; 99: 464–470.
9.
FeichtingerM.MossbockR.KarcherH.Evaluation of bone volume following bone grafting in patients with unilateral clefts of lip, alveolus and palate using a CT-guided three-dimensional navigation system.J Craniomaxillofac Surg.2006; 34: 144–149.
10.
FriedmanM.MafeeM.F.RayC.E.VenkatesanK.Three dimensional imaging for evaluation of head and neck tumors.Arch Otolaryngol Head Neck Surg.1993; 119: 601–607.
11.
FuhrmannA.SchulzeD.RotherU.VesperM.Digital transversal slice imaging in dental-maxillofacial radiology: from pantomography to digital volume tomography.Int J Comput Dent.2003; 6: 129–140.
12.
HamadaY.KondohT.NoguchiK.IinoM.IsonoH.IshiiH.MishimaA.KobayashiK.SetoK.Application of limited cone beam computed tomography to clinical assessment of alveolar bone grafting: a preliminary report.Cleft Palate Craniofac J.2005; 42: 128–137.
13.
HintzeH.WieseM.WenzelA.Cone beam CT and conventional tomography for the detection of morphological temporomandibular joint changes.Dentomaxillofac Radiol.2007; 36: 192–197.
14.
HirschfelderU.Radiological survey imaging of the dentition: dental CT versus orthopantomography [in German].Fortschr Kieferorthop.1994; 55: 14–20.
15.
HirschfelderU.PiechotE.SchulteM.LeherA.Abnormalities of the TMJ and the musculature in the oculo-auriculo-vertebral spectrum (OAV).J Orofac Orthop.2004; 65: 204–216.
16.
KalenderW.SeisslerW.KlotzE.VockE.Spiral volumetric CT with single-breath-hold technique, continuous transport and continuous scanner rotation.Radiology.1990; 176: 181–183.
17.
KitaiN.IguchiY.TakashimaM.MurakamiS.KreiborgS.KamijiT.TakadaK.Craniofacial morphology in an unusual case with nasal aplasia studied by roentgencephalometry and three-dimensional CT scanning.Cleft Palate Craniofac J.2004; 41: 208–213.
18.
KokichV.G.Surgical and orthodontic management of impacted maxillary canines.Am J Orthod Dentofacial Orthop.2004; 126: 278–283.
19.
LudlowJ.B.Davies-LudlowL.E.BrooksS.L.Dosimetry of two extraoral direct digital imaging devices: NewTom cone beam CT and Orthophos Plus DS panoramic unit.Dentomaxillofac Radiol.2003; 32: 229–234.
MarshJ.L.VannierM.W.Comprehensive Care for Craniofacial Deformities.St. Louis: Mosby;1985.
22.
MozzoP.ProcacciC.TacconiA.MartiniP.T.AndreisI.A.A new volumetric CT machine for dental imaging based on the cone-beam technique: preliminary results.Eur Radiol.1998; 8: 1558–1564.
23.
MüssigE.WortcheR.LuxC.J.Indications for digital volume tomography in orthodontics.J Orofac Orthop.2005; 66: 241–249.
24.
ParrD.G.StoelB.C.StolkJ.NightingaleP.G.StockleyR.A.Influence of calibration on densitometric studies of emphysema progression using computed tomography.Am J Respir Crit Care Med.2004; 170: 883–890.
25.
Schultze-MosgauS.HolbachL.M.WiltfangJ.Cherubism: clinical evidence and therapy.J Craniofac Surg.2003; 14: 201–206.
26.
SchulzeD.HeilandM.ThurmannH.AdamG.Radiation exposure during midfacial imaging using 4- and 16-slice computed tomography, cone beam computed tomography systems and conventional radiography.Dentomaxillofac Radiol.2004; 33: 83–86.
27.
SmolkaW.EggenspergerN.CarolloV.OzdobaC.IizukaT.Changes in the volume and density of calvarial split bone grafts after alveolar ridge augmentation.Clin Oral Implants Res.2006; 17: 149–155.
28.
SuleimanO.H.Radiation doses in pediatric radiology: influence of regulations and standards.Pediatr Radiol.2004; 34(Suppl 3): 242–246.
29.
Von WowernN.Cherubism: a 36-year long-term follow-up of 2 generations in different families and review of the literature.Oral Surg Oral Med Oral Pathol Oral Radiol Endod.2000; 90: 765–772.
