Möbius syndrome is a rare congenital condition that is characterized clinically by paralysis of a group of cranial nerves. It presents diverse manifestations that can have negative repercussions on the quality of life of affected individuals. This article presents a clinical case of a child with the syndrome and addressed the clinical manifestations and difficulties experienced during dental treatment. Knowledge of the etiopathological aspects and clinical manifestations of the condition is essential to perfecting treatments that aim to improve the quality of life of such individuals and their families.
BandimJ.M.VenturaL.O.MillerM.T.AlmeidaH.C.CostaA.E.S.Autism and Möbius sequence.Arq Neuropsiquiatr.2003; 61: 181–185.
2.
BavinckJ.N.WeaverD.D.Subclavian artery supply disruption sequence: hypothesis of a vascular etiology for Poland, Klippel-Feil, and Möbius anomalies.Am J Med Genet.1986; 23: 903–918.
3.
BenczeJ.Dental caries experience after Bell's palsy.Caries Res.1967; 1: 162–166.
4.
BriegelW.Neuropsychiatric findings of Möbius sequence—a review.Clin Genet.2006; 70: 91–97.
5.
Dal PizzolT.S.KnopF.P.MengueS.S.Prenatal exposure to misoprostol and congenital anomalies: systematic review and meta-analysis.Reprod Toxicol.2006; 22: 666–671.
6.
DomingosA.C.LopesS.L.C.P.AlmeidaS.M.BoscoloF.N.WhaitesE.J.Poland-Moebius syndrome: a case with oral anomalies.Oral Dis.2004; 10: 404–407.
7.
DonahueS.P.WengerS.L.SteeleM.W.GorinM.B.Broad-spectrum Möbius syndrome associated with a 1;11 chromosome translocation.Ophthalmic Paediatr Genet.1993; 14: 17–21.
8.
Fons-EstupiñáM.C.PóoP.ColomerJ.CampistolJ.Secuencia de Moebius: hallazgos clinicorradiológicos.Rev Neurol.2007; 44: 583–588.
GhabrialR.VersaceP.KourtG.LipsonA.MartinF.Syndromes with Craniosynostosis: Miscellaneous Syndromes. In: Möbius syndrome: features and etiology.J Pediatr Ophthalmol Strabismus.1998; 35: 304–311.
11.
GillbergC.SteffenburgS.Autistic behavior in Moebius syndrome.Acta Paediatr Scand.1989; 78: 314–316.
12.
GorlinR.J.CohenM.M.LevinL.S.Syndromes of the Head and Neck.Oxford: Oxford University Press;1990: 666–672.
13.
HaC.Y.MessiehaZ.S.Management of a patient with Möbius syndrome: a case report.Spec Care Dent.2003; 23: 111–116.
14.
HanissianA.S.FusteF.HayesW.T.DuncanJ.M.Möbius syndrome in twins.Am J Dis Child.1970; 120: 472–475.
15.
HendersonJ.L.The congenital facial diplegia syndrome: clinical features, pathology and etiology: a review of sixty-one cases.Brain.1939; 62: 381–403.
16.
KanemotoN.KanemotoK.KamodaT.HasegawaM.ArinamiT.A case of Moebius syndrome presenting with congenital vocal cord paralysis.Eur J Pediatr.2007; 166: 831–833.
17.
KorolukL.D.LaniganD.T.Moebius and Poland syndromes: a report of a case.Can Dent Assoc J.1989; 55: 647.
18.
KumarD.Moebius syndrome.J Med Genet.1990; 27: 122–126.
19.
LeongS.AshwellK.W.S.Is there a zone of vascular vulnerability in the fetal brain stem?Neurotoxicol Teratol.1997; 19: 265–275.
20.
LinK.J.WangW.N.Moebius syndrome: report of case.ASDC J Dent Child.1997; 64: 64–67.
21.
MacDermotK.D.WinterR.M.TaylorD.BaraitserM.Oculofacialbulbar palsy in mother and son: review of 26 reports of familial transmission within the “Möbius spectrum of defects.”J Med Genet.1990; 28: 18–26.
22.
Martí-HerreroM.Cabrera-LopezJ.C.ToledoL.Pérez-CandelaV.BonnetV.Sindrome de Moebius: tres formas diferentes de presentación.Rev Neurol.1998; 27: 975–978.
23.
MeyersonM.D.FousheeD.R.Speech, language and hearing in Moebius syndrome: a study of 22 patients.Dev Med Child Neurol.1978; 20: 357–365.
24.
MillerM.StrömlandK.GillbergC.JohanssonM.NilssonE.W.The puzzle of autism: an ophthalmologic contribution.Trans Am Ophthalmol Soc.1998; 96: 369–387.
25.
MöbiusP.J.Über angeborenen doppelseitige Abducens-Facialis-Lähmung.Münch Med Wochenschr.1888; 35: 91–108.
26.
NishikawaM.IchiyamaT.HayashiT.FurukawaS.Möbius-like syndrome associated with a 1;2 chromosome translocation.Clin Genet.1997; 51: 122–123.
PottieK.Is misoprostol teratogenic? Misoprostol use during early pregnancy and its association with Möbius syndrome.Can Fam Physician.1999; 15: 315–326.
29.
RizosM.NégronR.J.SermanN.Möbius syndrome with dental involvement: a case report and literature review.Cleft Palate Craniofac J.1998; 35: 262–268.
30.
Serpa-PintoM.V.X.MagalhãesM.H.C.G.NunesF.D.Moebius syndrome with oral involvement.Int J Paediatr Dent.2002; 12: 446–449.
31.
ShashikiranN.D.Subba ReddyV.V.PatilR.“Moebius syndrome”: a case report.J Indian Soc Ped Prev Dent.2004; 22: 96–99.
32.
SjögreenL.Andersson-NorinderJ.JacobssonC.Development of speech, feeding, eating, and facial expression in Möbius sequence.Int J Pediatr Otorhinolaryngol.2001; 60: 197–204.
33.
StrömlandK.SjögreenL.MillerM.GillbergC.WentzE.JohanssonM.NylénO.DanielssonA.JacobssonC.AnderssonJ.FernellE.Möbius sequence—a Swedish multidiscipline study.Eur J Paediatr Neurol.2002; 6: 35–45.
34.
SuvarnaJ.BagnawarM.DeshmukhC.T.Moebius syndrome with total anomalous pulmonary venous connection.Indian J Pediatr.2006; 73: 427–429.
35.
TemtamyS.A.McKusickV.A.The genetics of hand malformations.Birth Defects.1979; 14: 73–91.
36.
VerzijlH.T.F.M.PadbergG.W.ZwartsM.J.The spectrum of Möbius syndrome: an electrophysiological study.Brain.2005a; 128: 1728–1736.
37.
VerzijlH.T.F.M.ValkJ.de VriesR.PadbergG.W.Radiologic evidence for absence of the facial nerve in Möbius syndrome.Neurology.2005b; 64: 849–855.
38.
VerzijlH.T.F.M.van der ZwaagB.CruysbergJ.R.M.PadbergG.W.Möbius syndrome redefined: a syndrome of rhombencephalic maldevelopment.Neurology.2003; 61: 327–333.
39.
VerzijlH.T.F.M.van EsN.BergerH.J.C.PadbergG.W.van SpaendonckK.P.Cognitive evaluation in adult patients with Möbius syndrome.J Neurol.2005c; 252: 202–207.
