This study evaluates the effects of 8 years of insulinlike growth factor-I therapy on tooth development in patients with growth hormone insensitivity syndrome.
Methods:
Forty-nine panoramic radiographs were evaluated from eight patients (six boys, two girls). Seven teeth in the mandibular left region were graded according to the Demirjian system. Radiographs were taken at the start of insulinlike growth factor-I therapy and were continued at approximately yearly intervals for 8 years.
Results:
Three of six boys and one of two girls who began treatment with insulinlike growth factor-I at earlier ages experienced an increase in the rate of tooth development. One of six boys who began treatment with insulinlike growth factor-I at a later age had a slower rate of dental development. The patients had more rapid tooth maturation during the beginning of treatment. By the end of treatment, all patients had normal dental maturity for their age.
Conclusions:
Treatment of growth hormone insensitivity syndrome with insulinlike growth factor-I appears to lead to an increase in dental maturation, particularly in younger patients. After 8 years all patients had achieved normal dental development.
BackeljauwP., KissoondialA., UnderwoodL.E., SimmonsK.E.. Effects of 4-year treatment with recombinant human insulin-like growth factor-I (rh IGF-I) on craniofacial growth in children with growth hormone insensitivity syndrome (GHIS).Horm Res.1997; 48(Suppl 2): 15.
2.
BackeljauwP.F., UnderwoodL.E.. Therapy for 6.5–7.5 years with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome: a clinical research center study.J Clin Endocrinol Metab.2001; 86: 1504–1510.
3.
BackstromM.C., AineL., MakiR., KuuselaA.L., SievanenH., KoivistoA.M., IkonenR.S., MakiM.. Maturation of primary and permanent teeth in preterm infants.Arch Dis Child Fetal Neonatal Ed.2000; 83: F104–108.
4.
BurrenC.P., WoodsK.A., RoseS.J., TauberM., PriceD.A., HeinrichU., GilliG., Razzaghy-AzarM., Al-AshwalA., CrockP.A.. Clinical and endocrine characteristics in atypical and classical growth hormone insensitivity syndrome.Horm Res.2001; 55: 125–130.
5.
CameriereR., Flores-MirC., MauricioF., FerranteL.. Effects of nutrition on timing of mineralization in teeth in a Peruvian sample by the Cameriere and Demirjian methods.Ann Hum Biol.2007; 34: 547–556.
6.
ChailletN., DemirjianA.. Dental maturity in South France: a comparison between Demirjian's method and polynomial functions.J Forensic Sci.2004; 49: 1059–1066.
7.
ChailletN., NystromM., DemirjianA.. Comparison of dental maturity in children of different ethnic origins: international maturity curves for clinicians.J Forensic Sci.2005; 50: 1164–1174.
8.
ChailletN., NystromM., KatajaM., DemirjianA.. Dental maturity curves in Finnish children: Demirjian's method revisited and polynomial functions for age estimation.J Forensic Sci.2004; 49: 1324–1331.
9.
ChernausekS.D., BackeljauwP.F., FraneJ., KuntzeJ., UnderwoodL.E.. Long-term treatment with recombinant insulin-like growth factor (IGF)-I in children with severe IGF-I deficiency due to growth hormone insensitivity.J Clin Endocrinol Metab.2007; 92: 902–910.
10.
DavidA., MetherellL.A., ClarkA.J., Camacho-HubnerC., SavageM.O.. Diagnostic and therapeutic advances in growth hormone insensitivity.Endocrinol Metab Clin North Am.2005; 34: viii, 581–595.
11.
DavisP.J., HaggU.. The accuracy and precision of the “Demirjian system” when used for age determination in Chinese children.Swed Dent J.1994; 18: 113–116.
12.
DemirjianA., GoldsteinH.. New systems for dental maturity based on seven and four teeth.Ann Hum Biol.1976; 3: 411–421.
13.
DemirjianA., GoldsteinH., TannerJ.M.. A new system of dental age assessment.Hum Biol.1973; 45: 211–227.
14.
EidR.M., SimiR., FriggiM.N., FisbergM.. Assessment of dental maturity of Brazilian children aged 6 to 14 years using Demirjian's method.Int J Paediatr Dent.2002; 12: 423–428.
15.
FarahC.S., BoothD.R., KnottS.C.. Dental maturity of children in Perth, Western Australia, and its application in forensic age estimation.J Clin Forensic Med.1999; 6: 14–18.
16.
Flores-MirC., MauricioF.R., OrellanaM.F., MajorP.W.. Association between growth stunting with dental development and skeletal maturation stage.Angle Orthod.2005; 75: 935–940.
17.
FruchtS., SchnegelsbergC., Schulte-MontingJ., RoseE., JonasI.. Dental age in southwest Germany. A radiographic study.J Orofac Orthop.2000; 61: 318–329.
18.
GaethofsM., VerdonckA., CarelsC., de ZegherF.. Delayed dental age in boys with constitutionally delayed puberty.Eur J Orthod.1999; 21: 711–715.
19.
Hazza'aA.M., AI-JamalG.. Dental development in subjects with thalassemia major.J Contemp Dent Pract.2006; 7: 63–70.
20.
HegdeR.J., SoodP.B.. Dental maturity as an indicator of chronological age: radiographic evaluation of dental age in 6 to 13 years children of Belgaum using Demirjian methods.J Indian Soc Pedod Prev Dent.2002; 20: 132–138.
21.
ItoR.K., VigK.W., GarnS.M., HopwoodN.J., LoosP.J., SpaldingP.M., DeputyB.S., HoardB.C.. The influence of growth hormone (rhGH) therapy on tooth formation in idiopathic short-statured children.Am J Orthod Dentofacial Orthop.1993; 103: 358–364.
22.
KatajaM., NystromM., AineL.. Dental maturity standards in southern Finland.Proc Finn Dent Soc.1989; 85: 187–197.
23.
KornreichL., HorevG., SchwarzM., KarmazynB., LaronZ.. Craniofacial and brain abnormalities in Laron syndrome (primary growth hormone insensitivity).Eur J Endocrinol.2002; 146: 499–503.
24.
KotilainenJ., PirinenS.. Dental maturity is advanced in fragile X syndrome.Am J Med Genet.1999; 83: 298–301.
25.
LaronZ.. Consequences of not treating children with Laron syndrome (primary growth hormone insensitivity).J Pediatr Endocrinol Metab.2001; 14(Suppl 5): 1243–1248; discussion 1261–1262.
LiversidgeH.M., SpeechlyT.. Growth of permanent mandibular teeth of British children aged 4 to 9 years.Ann Hum Biol.2001; 28: 256–262.
31.
McKennaC.J., JamesH., TaylorJ.A., TownsendG.C.. Tooth development standards for South Australia.Aust Dent J.2002; 47: 223–227.
32.
NykanenR., EspelandL., KvaalS.I., KrogstadO.. Validity of the Demirjian method for dental age estimation when applied to Norwegian children.Acta Odontol Scand.1998; 56: 238–244.
33.
NystromM., HaatajaJ., KatajaM., EvalahtiM., PeckL., Kleemola-KujalaE.. Dental maturity in Finnish children, estimated from the development of seven permanent mandibular teeth.Acta Odontol Scand.1986; 44: 193–198.
34.
PirinenS.. Endocrine regulation of craniofacial growth.Acta Odontol Scand.1995; 53: 179–185.
35.
PrabhakarA.R., PandaA.K., RajuO.S.. Applicability of Demirjian's method of age assessment in children of Davangere.J Indian Soc Pedod Prev Dent.2002; 20: 54–62.
36.
SarnatH., KaplanI., PertzelanA., LaronZ.. Comparison of dental findings in patients with isolated growth hormone deficiency treated with human growth hormone (hGH) and in untreated patients with Laron-type dwarfism.Oral Surg Oral Med Oral Pathol.1988; 66: 581–586.
37.
SimmonsK.E.. Growth hormone and craniofacial changes: preliminary data from studies in Turner's syndrome.Pediatrics.1999; 104(4 pt 2): 1021–1024.
38.
TeivensA., MornstadH.. A comparison between dental maturity rate in the Swedish and Korean populations using a modified Demirjian method.J Forensic Odontostomatol.2001a; 19: 31–35.
39.
TeivensA., MornstadH.. A modification of the Demirjian method for age estimation in children.J Forensic Odontostomatol.2001b; 19: 26–30.
40.
TuncE.S., KoyuturkA.E.. Dental age assessment using Demirjian's method on northern Turkish children.Forensic Sci Int.2008; 175: 23–26.
41.
ZhaoJ., DingL., LiR.. Study of dental maturity in children aged 3–16 years in Chengdu [in Chinese].Hua Xi Yi Ke Da Xue Xue Bao.1990; 21: 242–246.
