Oral and Craniofacial Findings of Binder Syndrome: Two Case Reports

Abstract

Binder syndrome is a malformative midfacial alteration, known also as maxillonasal dysplasia or maxillonasal dysostosis. In this article, two cases of affected patients are reported, and the features of the condition are reviewed. One case presents a cleft lip. Hypotheses about etiology, pathogenesis, and classification of the syndrome are illustrated. This work provides a contribution for the delineation of a differential diagnostic procedure.

Keywords

Binder syndrome maxillonasal dysostosis maxillonasal dysplasia

Get full access to this article

View all access options for this article.

References

Binder

K.H.

Maxillo-nasal dysostosis, an arhinencephalic malformation complex (author's translation) [in German]. Dtsch Zahnarztl Z. 1962; 17: 438–444.

Dattani

M.T.

Martinez-Barbera

J.P.

Thomas

P.Q.

Brickman

J.M.

Gupta

Mårtensson

I.L.

Toresson

Fox

Wales

J.K.

Hindmarsh

P.C.

. Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet. 1998; 19: 125–133.

Delaire

Tessier

Tulasne

J.F.

Resche

Clinical and radiological aspects of maxillo-nasal dysostosis: “naso-maxillo-vertebral syndrome.” A study of 34 new cases (author's transl) [in French]. Rev Stomatol Chir Maxillofac. 1979; 80: 68–82.

Delaire

Tessier

Tulasne

J.F.

Resche

Clinical and radiologic aspects of maxillonasal dysostosis (Binder syndrome). Head Neck Surg. 1980; 3: 105–122.

Dyer

F.M.V.

Willmot

D.R.

Maxillonasal dysplasia, Binder's syndrome: review of the literature and case report. J Orthod. 2002; 29: 15–21.

Ferguson

J.W.

Thompson

R.P.J.

Maxillonasal dysostosis (Binder syndrome); a review of literature and case reports. Eur J Orthod. 1985; 7: 145–148.

Gorlin

R.J.

Cohen

Jr Levin

L.S.

Syndromes of the Head and Neck. New York: Oxford University Press; 1990: 813–815.

Holström

Clinical and pathologic features of maxillonasal dysplasia (Binder's syndrome): significance of the prenasal fossa on etiology. Plast Reconstr Surg. 1986; 78: 559–567.

Hopkin

G.B.

Hypoplasia of the middle third of the face associated with congenital absence of the anterior nasal spine, depression of the nasal bones, and Angle class III malocclusion. Br J Plast Surg. 1963; 16: 146–153.

10.

Horswell

B.B.

Holmes

A.D.

Barnett

J.S.

Lavant

B.A.

Maxillonasal dysplasia (Binder's syndrome): a critical review and a case study. J Oral Maxillofac Surg. 1987; 45: 114–122.

11.

Howe

A.M.

Lipson

A.H.

Sheffield

L.J.

Haan

E.A.

Halliday

J.L.

Jenson

David

D.J.

Webster

W.S.

Prenatal exposure to phenytoin, facial development, and a possible role for vitamin K. Am J Med Genet. 1995; 58: 238–244.

12.

Jackson

I.T.

Moos

K.F.

Sharpe

D.T.

Total surgical management of Binder's syndrome. Ann Plast Surg. 1981; 7: 25–34.

13.

Jaillet

Robert-Gnansia

Till

Vinciguerra

Edery

Biliary lithiasis in early pregnancy and abnormal development of facial and distal limb bones (Binder syndrome): a possible role for vitamin K deficiency. Birth Defects Res A Clin Mol Teratol. 2005; 73: 188–193.

14.

Levaillant

J.M.

Moeglin

Zouiten

Bucourt

Burglen

Soupre

Baumann

Jaquemont

M.L.

Touraine

Picard

. Binder phenotype: clinical and etiological heterogeneity of the so-called Binder maxillonasal dysplasia in prenatally diagnosed cases, and review of literature. Prenat Diagn. 2009; 29: 140–150.

15.

Narcy

Foucaud

Cargill

Sablier

Le Guillou

Contencin

Navarro

The association of megaesophagus, Binder's syndrome and dysautonomia: a new neurocristopathy. Arch Fr Pediatr. 1987; 44: 119–121.

16.

Nedev

P.K.

The Binder syndrome: review of the literature and case report. Int J Pediatr Otorhinolaryngol. 2008; 72: 1573–1576.

17.

Noyes

F.B.

Case report. Angle Orthod. 1939; 9: 160–165.

18.

Olow-Nordenram

Thilander

The craniofacial morphology in persons with maxillonasal dysplasia (Binder syndrome). A longitudinal cephalometric study of orthodontically treated children. Am J Orthod Dentofacial Orthop. 1989; 95: 148–158.

19.

Quarrel

O.W.J.

Koch

Huges

H.E.

Maxillonasal dysplasia (Binder's syndrome). J Med Genet. 1990; 27: 384–387.

20.

Rune

Sarnäs

K.V.

Selvik

Jacobsson

Posteroanterior traction in maxillonasal dysplasia (Binder syndrome). A roentgen stereometric study with the aid of metallic implants. Am J Orthod. 1982; 81: 65–70.

21.

Sheffield

L.J.

Halliday

J.L.

Jensen

Maxillonasal dysplasia (Binder's syndrome) and chondrodysplasia punctata. J Med Genet. 1991; 28: 503–504.

22.

Striker

Van der Meulen

J.C.

Raphael

Mazzola

Craniofacial Malformations. Edinburgh: Churchill Livingstone; 1990.

23.

Tessier

Tulasne

J.F.

Delaire

Resche

Therapeutic aspects of maxillonasal dysostosis (Binder syndrome). Head Neck Surg. 1981; 3: 207–215.