The reproductive history was studied to evaluate if the three types of solitary, nonsyndromic clefts: cleft lip (CL), cleft lip and palate (CLP), and cleft palate (CP) are homogeneous entities. Occurrence of fetal loss, maternal health, and drug consumption of the mother during the pregnancy were compared in cases involving three types of clefts. Data was gathered from 87 children with clefts, 55 males and 32 females. Spontaneous abortions and vaginal bleeding were found to occur significantly more often in the (older) mother of a CLP child. This suggests that the factors involved in the etiology of CLP differ from the factors involved in CL and CP. Therefore, grouping of data of the three types of clefts in studies on the etiology should be avoided.
BearJ.C.Additional data on sponlaneous abortion and facial cleft malformations.Clin Genet1983; 24: 407–412.
2.
BearJ.C.Liability to cleft lip and palate, Interpreting the human data. In: KalterH., ed. Issues and reviews in teratology. Vol. 4.New York: Plenum Press, 1988: 163–204.
3.
BixlerD.Genetics and clefting.Cleft Palate J1981; 18: 10–18.
4.
DrillienC.M., IngramT.T.S., WilkinsonE.M.The causes and natural history of cleft lip and palate.Edinburgh, London: E & S Livingstone,1981.
5.
DronamrajuK.R., BixlerD.Fetal mortality and cleft lip with or without cleft palate.Clin Genet1983a; 23: 38–40.
6.
DronamrajuK.R., BixlerD.Fetal mortality in oral cleft families (VI): a search for early embryonic and zygotic mortality.Clin Genet1983b; 24: 346–349.
7.
DronamrajuK.R., BixlerD.Fetal mortality in oral cleft families (V): studies of sporadic vs familial and pure vs syndromic clefts.Clin Genet1984a; 25: 314–317.
Felix-SchollaartB.Solitary, non-syndromic cleft lip and/or palate. A comparison between cleft lip, cleft lip and palate, and cleft palate on epidemiologic characteristics and growth. Thesis.Amsterdam: Rodopi,1989.
10.
FienbergS.E.The analysis of cross-classified categorical data.London, Cambridge: MIT Press,1980.
11.
Fogh-AndersenP.Inheritance of harelip and cleft palate. Thesis.Copenhagen: Nyt Nordisk Forlag,1942.
MardenP.M., SmithD.W., McDonaldM.J.Congenital anomalies in the new bom infant, including minor variations. A study of 4,412 babies by surface examination for anomalies and buccal smear for sex chromatin.J Pediatr1964; 64: 358–371.
15.
NiswanderJ.D., MacLeanC.J., ChungC.S., DronamrajuK.R.Sex ratio and cleft lip with or without cleft palate.Lancet1972; ii: 858–860.
16.
RintalaA., PönkäA., SarnaS., StegarsT.Cleft lip and palate in Finland in 1948–75: correlations to infections, seasonal and yearly variations.Scand J Plast Reconstr Surg1983; 17: 197–201.
17.
RintalaA., StegarsT.Increasing incidence of clefts in Finland; reliability of hospital records and central register of congenital malformations.Scand J Plast Reconstr Surg1982; 16: 35–40.
18.
SaxénI.Cleft lip and palate in Finland: parental histories, course of pregnancy and selected environmental factors.Int J Epidemiol1974; 3: 263–270.
19.
SaxénI.Epidemiology of cleft lip and palate. An attempt to rule out chance correlations.Br J Prev Soc Med1975; 29: 103–110.
20.
ShprintzenR.J., Siegel-SadewitzV.L., AmatoJ., GoldbergR.B.Anomalies associated with cleft lip, cleft palate, or both.Am J Med Genet1985; 20: 585–595.
21.
Vermeÿ-KeersChr, MazzolaR.F., Van der MeulenJ.C., StricklerM.Cerebro-craniofacial and craniofacial malformations: an embryological analysis.Cleft Palate J1983; 20: 128–145.
22.
WatsonA.C.H.Embryology of cleft lip and palate. In: EdwardsM., WatsonA.C.H. eds. Advances in management of cleft palate.New York: Churchill Livingstone, 1980: 27–36.
