Histological Evaluation of Autogenous Iliac Particulate Cancellous Bone and Marrow Grafted to Alveolar Clefts—A Preliminary Report of Five Young Adult Cases

Abstract

Objective

We histologically evaluated iliac particulate cancellous bone and marrow (PCBM) grafted to alveolar clefts in five young adults with cleft lip and palate.

Patients and Methods

Five young adults with cleft lip and palate underwent secondary alveolar bone grafting. The mean age of the patients was 21.2 years (range = 17 to 27 years). Bone specimens were taken from the graft site 5 to 10 months after the surgery simultaneously with implant fixture placement (two cases), vestibuloplasty (two cases), and rebone grafting (one case). These five bone specimens were prepared and stained with hematoxylin and eosin and examined microscopically.

Result

One specimen, taken 5 months after surgery, showed immature trabecular bone partially lined by osteoblasts. The remaining four specimens showed well-mineralized trabeculae and fatty change in the marrow space.

Conclusion

In young adult cases, PCBM remodeled after grafting and became mature bone about 5 to 6 months after the surgery.

Keywords

alveolar bone grafting cleft lip and palate histological evaluation particulate cancellous bone and marrow

Get full access to this article

View all access options for this article.

References

Amanat

Langdom

J.D.

. Secondary alveolar bone grafting in clefts of the lip and palate. J Cranio-Maxillo-Fac Surg. 1991; 19: 7–14.

Bergland

Semb

Abyholum

F.E.

. Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment. Cleft Palate J. 1986; 23: 175–205.

Boyne

P.J.

Sands

N.R.

. Combined orthodontic–surgical management of residual palato-alveolar defect. Am J Orthod. 1976; 70: 20–37.

Enemark

Sindet-Pederson

Bungaard

. Long-term results after secondary bone grafting of alveolar clefts. J Oral Maxillofac Surg. 1987; 45: 913–918.

Hall

H.D.

Posnick

J.C.

. Early results of secondary bone grafts in 106 alveolar clefts. J Oral Maxillofac Surg. 1983; 41: 289–294.

LaRossa

Buchman

Rothkopf

D.M.

Mayro

Randall

. A comparison of iliac and cranial bone in secondary grafting of alveolar clefts. Plast Reconstr Surg. 1995; 96: 789–797.

Marx

Miller

R.I.

Ehler

W.J.

Hubbard

Malinin

T.I.

. A comparison of particulate allogenic and particulate autogenous bone grafts into maxillary alveolar clefts in dog. J Oral Maxillofac Surg. 1984; 42: 3–9.

Paulin

Astrand

Rosenquist

J.B.

Bartholdson

. Intermediate bone grafting of alveolar clefts. J Cranio-Maxillo-Fac Surg. 1988; 16: 2–7.

Ronchi

Chiapasco

Frattini

. Endosseous implants for prosthetic rehabilitation in bone grafted alveolar clefts. J Cranio-Maxillo-Fac Surg. 1995; 23: 382–386.

10.

Rosenquist

J.B.

Rosenquist

Sund

. Effects of bone grafting on maxillary bone healing in the growing pig. J Oral Maxillofac Surg. 1982; 40: 566–569.

11.

Samman

Cheung

L.K.

Tideman

. A comparison of alveolar bone grafting with and without simultaneous maxillary osteotomies in cleft palate patients. J Oral Maxillofac Surg. 1994; 23: 65–70.

12.

Sindet-Pederson

Enemark

. Comparative study of secondary and late secondary bone-grafting in patients with residual clefts defects. Short-term evaluation. Int J Oral Surg. 1985; 14: 389–398.