In this perspective we consider new aspects of ligand-induced estrogen receptor α (ERα) degradation. What are the possible roles of CSN5/Jab1 and the CSN complex in this process? We compare hormone (estrogen) or pure antagonist (fulvestrant) induced degradation of ERα and review the effects of kinase-inhibitors and CRM1-dependent nuclear export on ERα degradation and transcription activation. A model for ERα action integrating these new actors is proposed and the relation between hormone-induced ERα degradation and transcription-activation is discussed.
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