Abstract
Birth cohort initiatives, such as 'Born in Bradford', provide a unique opportunity to study the influence of socio-economic and environmental factors acting in pregnancy, birth and infancy on the development of dental caries in later life. This paper describes a feasibility study which established the processes required, and outcomes of, successful linkage of oral health data collected by the 2013 three-year-old national dental epidemiology survey with the Born in Bradford birth cohort database. The necessary processes included achieving research permissions and ethical approval; creation of a data sharing agreement; ensuring data security and encrypted data transfer. With regard to the outcomes, a robust a priori statistical plan was developed. 152 three-year-old children were examined for the 2013 dental epidemiology survey in Bradford, and of those, 69 parents consented to data linkage believing that their child was part of the Born in Bradford cohort. However, only 36 of these 69 children were participating in the cohort. Of these, six children had obvious dentinal caries experience (dmft ⟩0). There was insufficient power with such small numbers, to examine the association between birthweight and dental caries at the age of three-years-old. Key learning points from this feasibility study have informed the design of a larger study to link the 2014/5 five-year-old dental epidemiology surveys with the Born in Bradford cohort. This paper reveals the important methodological considerations for future data linkages between routine health data and research data.
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