The 24-Hour LH Test in the Diagnosis and Assessment of Response to Treatment of Patients with Anorexia Nervosa

Abstract

Studies of patterns of lutenizing hormone (LH) secretion in anorexia nervosa are reviewed. Restoration of ideal weight is not always associated with return to adult circadian LH secretion patterns. Abnormalities in LH secretion (immature patterns) may represent a biological “marker” of active anorexia nervosa.

Get full access to this article

View all access options for this article.

References

Frisch

R. E.

and Revelle

, Height and Weight at Menarche and a Hypothesis of Critical Body Weights and Adolescent Events, Science, 169, pp. 397–398, 1970.

Frisch

F. E.

and McArthur

, Menstrual Cycles: Fatness as Determinant of Minimal Weight for Height Necessary for Their Maintenance or Onset, Science, 185, pp. 949–951, 1974.

LeRoy

L. E.

, Famine Amenorrhea (Seventeenth-Twentieth Centuries), Ann. ESC, 24, pp. 1589–1601, 1969.

Crisp

A. H.

and Stonehill

, Relation Between Aspects of Nutritional Disturbance and Menstrual Activity in Primary Anorexia Nervosa, Brit. Med. J., 3, pp. 149–151, 1971.

Kay

D. W. K.

and Leigh

, Naturan History, Treatment, and Prognosis of Anorexia Nervosa, Based on a Study of 38 Patients, J. Ment. Sci., 100, pp. 411–431, 1954.

Halmi

K. A.

, Anorexia Nervosa: Demographic and Clinical Features in 94 Cases, Psychosom. Med., 36, pp. 18–26, 1974.

Bell

E. T.

Harkness

R. A.

Loraine

J. A.

and Russell

G. F. M.

, Hormone Assay Studies in Patients with Anorexia Nervosa, Acta. Endocrinol. (Kbh), 51, pp. 140–148, 1966.

Russell

G. F. M.

, Psychological and Nutritional Factors in Disturbance of Menstrual Function and Ovulation, Postgrad. Med. J., 48, pp. 10–13, 1972.

Katz

J. L.

Boyar

R. M.

Weiner

Gorynski

Roffwarg

, and Hellman

, Toward an Elucidation of the Psychoendocrinology of Anorexia Nervosa, Sachar

(ed.), Hormones, Behavior, and Psychopathology, Raven Press, New York, pp. 263–283, 1976.

10.

Boyar

R. M.

Katz

Finkelstein

J. W.

Kapen

Weiner

Weitzman

E. D.

and Hellman

, Anorexia Nervosa: Immaturity of the 24-Hour Luteinizing Hormone Secretory Pattern, New Engl. J. Med., 291, pp. 861–865, 1974.

11.

Brown

G. M.

Garfinkel

P. E.

Jeuniewic

and Stancer

H. C.

, Endocrine Profiles in Anorexia Nervosa, Vigersky

(ed.), Anorexia Nervosa, Raven Press, New York, pp. 123–135, 1977.

12.

Hellman

Nakada

Curti

Weitzman

Kream

Roffwarg

Ellman

Fukushima

and Gallagher

T. F.

, Cortisol is Secreted Episodically by Norman Man, J. Clini Endocrinol. Metabl., 30, pp. 411–422, 1970.

13.

Feighner

J. P.

Robins

Guze

S. B.

Woodruff

R. A.

Jr. Winokur

and Munoz

, Diagnostic Criteria for Use in Psychiatric Research, Arch. Gen. Psychiat., 26, pp. 57–63, 1972.

14.

Midgley

A. R.

Jr. , Radioimmunoassay: A Method for Human Chorionic Gonadotropin and Human Luteinizing Hormone, Endocrinology, 79, pp. 10–18, 1966.

15.

Boyar

Perlow

Hellman

Kapen

and Weitzman

, Twenty-Four Patterns of Luteinizing Hormone Secretion in Normal Men with Sleep Stage Monitoring, J. Clin. Endocrinol. Metab., 35, pp. 73–81, 1972.

16.

Katz

J. L.

Boyar

R. N.

Roffwarg

Hellman

and Weiner

, LHRH Responsiveness in Anorexia Nervosa: Intactness Despite Prepubertal Cricadian LH Pattern, Psychosom. Med., 39, pp. 241–251, 1977.

17.

Beumont

P. J. V.

George

G. C. W.

Pimstone

B. L.

and Vinik

A. I.

, Body Weight and the Pituitary Response to Hypothalamic Releasing Hormones in Patients with Anorexia Nervosa, J. Clin. Endocrinol. Metab., 43, pp. 487–496, 1976.

18.

Warren

M. P.

and Wiele

Vande R. L.

, Clinical and Metabolic Features of Anorexia Nervosa, Amer. J. Obstet. Gynecol, 117, pp. 435–449, 1973.

19.

Mecklenburg

R. S.

Loriaux

D. L.

Thompson

R. H.

and Lipsett

, Hypothalamic Dysfunction in Patients with Anorexia Nervosa, Medicine, 53, (Baltimore), pp. 147–159, 1974.

20.

Wiegelmann

and Solbach

H. G.

, Effects of LH-RH on Plasma Levels of LH and FSH in Anorexia Nervosa, Horm. Metab. Res., 4, pp. 404, 1972.

21.

Yoshimoto

Moridera

, and Imura

, Restoration of Normal Pituitary Gonadotropin Reserve by Administration of Luteinizing Hormone-Releasing Hormone in Patients with Hypogonadotropic Hypogonadism, New Engl. J. Med., 292, pp. 242–245, 1975.

22.

Wurtman

R. J.

and Fernstrom

J. D.

, Control of Brain Neurotransmitter Synthesis by Precursor Availability and Nutritional State, Biochem. Pharmacol. 25, pp. 1691–1696, 1976.