Effect of Aspirin Pre- and Postburn on Survival of Experimental Intermediate Burns in Rats

Abstract

French

Background:

Burns are a major health care problem. Early treatment increases survival of intermediate burn zones, thus decreasing morbidity, mortality, surgery, and hospitalization. Previously, aspirin was shown to improve burn perfusion and increase failing flap survival.

Objective:

Owing to similarities between failing flaps and intermediate burn zones, we conducted this study to evaluate the effect of aspirin on intermediate burn zone survival.

Methods:

An intermediate burn was created in 30 rats randomly divided into three experimental groups: pre- and postburn aspirin groups and a control group. Final burn survival was evaluated on day 7.

Results:

No statistical difference was observed between the test and control groups. Both aspirin regimens failed to improve intermediate burn survival.

Conclusion:

Presumably, administration of aspirin could not prevent the noxious tissue events of burn injury that cause cell death. Possibly, different dosages or modes of administering aspirin could have a beneficial effect on burn wound survival.

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