Primary yolk sac tumor of the liver is an extremely rare neoplasm, with fewer than 20 cases reported. We evaluated 2 pediatric cases (21-month-old and 23-month-old female patients), who presented with liver masses and markedly raised serum α-fetoprotein (AFP). One patient received a partial hepatectomy and another patient underwent a liver biopsy, both of which showed characteristic features of yolk sac tumor, with tumor cells staining strongly positive for AFP. There was no evidence of an extrahepatic primary source. Both of our patients have been healthy, without evidence of recurrent tumor, and their AFP level remains in the normal range after their chemotherapeutic treatments.
McKenneyJKHeerema-McKenneyARouseRV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol2007;14:69–92.
3.
GilbertKLBergmanSDoddLGVolmarKECreagerAJ. Cytomorphology of yolk sac tumor of the liver in fine-needle aspiration: a pediatric case. Diagn Cytopathol2006;34: 421–423.
4.
NaritaTMoriyamaYItoY. Endodermal sinus (yolk sac) tumour of the liver. A case report and review of the literature. J Pathol1988; 155:41–47.
5.
FinegoldM. Hepatic tumors in childhood. In: RussoPRuchelliEPiccoliD, eds. Pathology of pediatric gastrointestinal and liver disease. New York: Springer, 2004;300–346.
6.
O'SullivanPDanemanAChanHS. Extragonadal endodermal sinus tumors in children: a review of 24 cases. Pediatr Radiol1983;13:249–257.
7.
YanQH. Primary endodermal sinus tumor of the liver–a case report with a discussion on embryogenesis. Zhonghua Zhong Liu Za Zhi1982;4:224–225.
8.
NatoriTTeshimaSKikuchiY. Primary yolk sac tumor of the liver. An autopsy case with ultrastructural and immunopathological studies. Acta Pathol Jpn1983;33:555–564.
9.
VillaschiSBalistreriP. Endodermal sinus tumour of the liver. Histopathology1991;18:86–88.
10.
WhelanJSStebbingsWOwenRACalneRClarkPI. Successful treatment of a primary endodermal sinus tumor of the liver. Cancer1992;70:2260–2262.
11.
HiguchiTKikuchiM. Yolk sac tumor of the liver treated with transcatheter arterial embolization. Am J Gastroenterol1993;88: 1125–1126.
12.
MorinagaSNishiyaHInafukuT. Yolk sac tumor of the liver combined with hepatocellular carcinoma. Arch Pathol Lab Med1996;120:687–690.
13.
WongNAD'CostaHBarryREAldersonDMoorghenM. Primary yolk sac tumour of the liver in adulthood. J Clin Pathol1998;51:939–940.
14.
GunawardenaSASiriwardanaHPWickramasingheSYMaduraweMNFernandoR. Primary endodermal sinus (yolk sac) tumour of the liver. Eur J Surg Oncol2002;28:90–91.
15.
ToumiNChaumette-PlankaertMTCherquiDde RevelTDuvillardPTheodoreC. Germ cell tumors. Case 3. Primary yolk sac tumor of the liver. J Clin Oncol2004;22:1756–1758.
16.
LenciITariciottiLBaiocchiL. Primary yolk sac tumor of the liver: incidental finding in a patient transplanted for hepatocellular carcinoma. Transpl Int2008;21:598–601.
17.
HartWR. Primary endodermal sinus (yolk sac) tumor of the liver. First reported case. Cancer1975;35:1453–1458.
18.
CrossSSVariendS. Combined hepatoblastoma and yolk sac tumor of the liver. Cancer1992;69:1323–1326.
19.
WakelyPEJrKrummelTMJohnsonDE. Yolk sac tumor of the liver. Mod Pathol1991;4:121–125.
20.
VermaMAgarwalSMohtaA. Primary mixed germ cell tumour of the liver–a case report. Indian J Pathol Microbiol2003;46:658–659.
21.
AbramsonLPPillaiSActonRMelin-AldanaHSuperinaR. Successful orthotopic liver transplantation for treatment of a hepatic yolk sac tumor. J Pediatr Surg2005;40:1185–1187.
