A time sampling procedure was used to observe the behavioral effects of IP bufotenine injection in the rat. The results indicated an attenuation of locomotor activity which varied directly as a function of drug dosage. In addition, all response components typically associated with a general activity pattern were selectively affected by bufotenine. Interpretation of the response decrement in terms of a generalized motor loss was not supported by other aspects of the data. Evidence suggesting that behavioral changes following bufotenine treatment are due to a disruption of sensory processes was discussed.
References
1.
BindraD. B.SpinnerN.Response to different degrees of novelty: the incidence of various activities. J. exp. Anal. Behav., 1958, 1, 341–350.
2.
EvartsE. C.Some effects of bufotenine and LSD on the monkey. AMA. Arch. Neurol. Psychiat., 1956, 75, 49–53.
3.
EvartsE. C.LandauW.FreygangW.MarshallW. H.Some effects of LSD and bufotenine on electrical activity in the cat's visual system. Amer. J. Physiol., 1955, 182, 594–598.
4.
FabingH. D.HawkinsJ. R.Intravenous bufotenine injection in the human being. Science, 1956, 123, 886–887.
5.
FischerW.LagravereT. A. F.VazquezA. J.Di StefanoA. O.A bufotenine-like substance in the urine of schizophrenics. J. nerv. ment. Dis., 1961, 133, 441–444.
6.
HellerB.Influence of treatment with an amine oxidase inhibitor on the excretion of bufotenine, and the clinical symptoms in chronic schizophrenic patients. Int. J. Neuropsychiat., 1966, 2, 193–203.
7.
MahlerD. J.HumhollerF. L.Effects of LSD-25 and bufotenine on performance of trained rats. Proc. Soc. Exp. Biol. Med., 1959, 102, 697–701.
8.
MaireF. W.HixonA. C.Behavioral and performance changes in trained rats following bufotenine injection. Int. J. Neuropsychiat., 1966, 2, 135–142.
9.
MorazziA. S.HartE. R.Relationship of hallucinogens to adrenergic cerebral synapses. Science, 1955, 121, 365.
