Geophysical Variables and Behavior: Xci. Ambulatory Behavior in Rats following Prenatal Exposures to Complex Magnetic Fields Designed to Interact with Genetic Expression
Restricted accessResearch articleFirst published online February, 2001
Geophysical Variables and Behavior: Xci. Ambulatory Behavior in Rats following Prenatal Exposures to Complex Magnetic Fields Designed to Interact with Genetic Expression
A total of 45 litters were exposed during their entire prenatal development to one of two complex patterns of magnetic fields whose strengths varied within one of four intensity ranges between 10 nT and 1000 nT or to sham-field conditions. The litters exposed to the most complex pattern, composed of 50 200-msec. presentations of different pulses for 10 sec. every 50 sec., displayed more ambulation in an open field at 21 days of age than the litters that had been exposed continuously to a repetitive frequency-modulated field or to sham-field conditions. This treatment explained 25% of the variance in the numbers of squares traversed. The results suggest that complexity of the applied magnetic field during prenatal development may be more important than intensity for permanently affecting neuronal organization and behavior.
Get full access to this article
View all access options for this article.
References
1.
BerridgeM. J. (1997) Elementary and global aspects of calcium signalling. Journal of Physiology, 499, 291–306.
2.
DolmetschR. E.XuK.LewisR. S. (1998) Calcium oscillations increase the efficiency and specificity of gene expression. Nature, 393, 933–936.
3.
FlemingJ. L.PersingerM. A.KorenS. A. (1994) Magnetic pulses elevate nociceptive thresholds: Comparisons with opiate receptor compounds in normal and seizure-induced brain-damaged rats. Electro- and Magnetobiology, 13, 67–75.
4.
HajjarR. J.BonventreJ. V. (1991) Oscillations of intracellular calcium induced by vasopressin in individual Fura-2-loaded Mesangial cells. The Journal of Biological Chemistry, 266(32), 21589–21594.
5.
LednevV. V. (1991) Possible mechanism for the influence of weak magnetic fields on biological systems. Bioelectromagnetics, 12, 71–75.
6.
LiW-H.LlopisJ.WhitneyM.ZloxarnikG.TsienR. Y. (1998) Cell-permeant cage LnsP3 ester shows that Ca + + spike frequency can optimize gene expression. Nature, 393, 936–940.
7.
LiburdyR. P.CallahanD. E.HarlandJ.DunhamE.SlomaT. R.YaswenP. (1993) Experimental evidence for 60 Hz magnetic fields operating through signal transduction cascade. Federation of European Biochemical Societies, 334, 301–308.
8.
MaaloeO.MaaloeN.KjeldgaardN. (1966) Control of macromolecular synthesis. New York: Benjamin.
9.
MichonA. L.PersingerM. A. (1997) Experimental simulation of the effects of increased geomagnetic activity upon nocturnal seizures in epileptic rats. Neuroscience Letters, 224, 53–56.
10.
O'ConnorR. P.PersingerM. A. (1999) Geophysical variables and behavior: LXXXV. Sudden infant death, bands of geomagnetic activity, and pcl (0.2 to 0.5 Hz) geomagnetic pulsations. Perceptual and Motor Skills, 88, 391–397.
11.
OssenkoppK-P.MazmanianD. S. (1985) The principle of aggregation in psychobiological correlational research: An example from the open-field. Animal Learning and Behavior, 13, 339–344.
12.
PersingerM. A. (1969) Open-field behaviours in rats exposed prenatally to a low intensity-low frequency, rotating magnetic field. Developmental Psychohiology, 2, 168–171.
13.
PersingerM. A. (1999) On the nature of space-time in the observation of physical events in science. Perceptual and Motor Skills, 88, 1210–1216.
14.
PersingerM. A.CookL. L.KorenS. A. (2000) Suppression of experimental allergic encephalomyelitis in rats exposed nocturnally to magnetic fields. International Journal of Neuroscience, 100, 107–116.
15.
PersingerM. A.LaereniereG. F. (1977) Space-time transients and unusual events. Chicago, IL: Nelson-Hall.
16.
PersingerM. A.TillerS. G.KorenS. A. (2000) Experimental simulation of a haunt experience and elicitation of paroxysmal electroencephalographic activity by transcerebral complex magnetic fields: Induction of a synthetic “ghost”?Perceptual and Motor Skills, 90, 659–674.
17.
RichardsP. M.PersingerM. A.KorenS. A. (1993) Modification of activation and evaluation of properties of narratives by weak complex magnetic field patterns that simulate limbic burst firing. International Journal of Neuroscience, 71, 71–85.
18.
RichardsP. M.PersingerM. A.KorenS. A. (1996) Modification of semantic memory in normal subjects by application across the temporal lobes of a weak (1 microT) magnetic field structure that promotes long-term potentiation in hippocampal slices. Electro- and Magnetobiology, 15, 141–148.
19.
SandykR. (1993) The effects of pico Tesla range magnetic fields on perceptual organization and visual memory in Parkinsonism. International Journal of Neuroscience, 73, 207–219.
20.
SandykR. (1995) Improvement of right hemispheric functions in a child with Gilles de la Tourette's syndrome by weak electromagnetic fields. International Journal of Neuroscience, 81, 199–213.
21.
SeamanR. L.BeltM. L.DoyleJ. M.MathurS. P. (1999) Hyperactivity caused by a nitric oxide synthase inhibitor is countered by ultra-wideband pulses. Bioelectromagnetics, 20, 431–439.
22.
SouthernW. E. (1971) Gull orientation by magnetic cues: A hypothesis revisited. Annals of the New York Academy of Sciences, 188, 295–311.
23.
StewartL. S.PersingerM. A. (2000) Pretraining exposure to physiologically patterned electromagnetic stimulation attenuates fear-conditioned analgesia. International Journal of Neuroscience, 100, 91–98.
24.
St-PierreL. S.PersingerM. A.KorenS. A. (1998) Experimental induction of intermale aggressive behavior in limbic rats by weak, complex magnetic fields: Implications for geomagnetic activity and the modern habitat?International Journal of Neuroscience, 96, 149–159.
25.
TangY.OthmerH. G. (1995) Frequency encoding of excitable systems with applications to calcium oscillations. Proceedings for the National Academy of Science, 92, 7869–7873.
26.
ThomasA. W.KavaliersM.PratoF. S.OssenkoppK-P. (1997) Antinociceptive effects of a pulsed magnetic field in the land snail, Cepaea nemoralis. Neuroscience Letters, 222, 107–110.
