A Biochemical Analysis of People with Chronic Fatigue Who Have Irlen Syndrome: Speculation concerning Immune System Dysfunction

Abstract

This study investigated the biological basis of visual processing disabilities in adults with Chronic Fatigue Syndrome. The study involved 61 adults with symptoms of Chronic Fatigue Syndrome who were screened for visual processing problems (Irlen Syndrome) and divided into two groups according to the severity of symptoms of Irlen Syndrome. Significant variations were identified in blood lipids and urine amino and organic acids of the two groups, which may be indicative of activation of the immune system due to some infective agent. It was suggested that metabolic profiling may help the development of more valid diagnostic categories and allow more investigation of immune system dysfunction as a possible causal factor in a range of learning and behaviour disorders.

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References

Abbey

Nestel

P. J.

(1994) Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in the diet. Atherosclerosis, 106, 99–107.

Arao

Soushi

Sato

Moriishi

Ando

Yamada

Padilla

Uno

Kurata

(1997) Infection of a human retinal pigment epithelial cell line with human herpes virus 6 variant A. Journal of Medical Virology, 53, 105–110.

Armstrong

F. D.

Seidel

J. F.

Swales

T. P.

(1993) Pediatric HIV infection: A neuropsychological and educational challenge. Journal of Learning Disabilities, 26, 92–103.

Baker

S. M.

(1985) A biochemical approach to the problem of dyslexia. Journal of Learning Disabilities, 18, 581–584.

Barker

T. A.

Torgesen

J. K.

Wagner

R. K.

(1992) The role of orthographic processing skills on five different reading tasks. Reading Research Quarterly, 27, 335–345.

Bulmer

(1994) Sensory overload and general well being: Can adults be helped by using Irlen lenses? Unpublished honours thesis, Chester College of Higher Education, Chester, UK.

Carroll

T. A.

Mullaney

Eustace

(1994) Dark adaptation in disabled readers screened for Scotopic Sensitivity Syndrome. Perceptual and Motor Skills, 18, 131–141.

Comings

(1996) New genetic findings show ADHD is not a myth. Adult ADD conference: Bringing the pieces together. Ann Arbour, Michigan, 16–18 May.

Croyle

(1998) Rate of reading, visual processing, colour and contrast. Australian Journal of Learning Disabilities, 3(3), 13–20.

10.

Demb

J. B.

Boynton

G. M.

Best

Heeger

D. J.

(1998) Psychophysical evidence for a magnocellular pathway deficit in dyslexia. Vision Research, 38, 1555–1559.

11.

Demb

J. B.

Boynton

G. M.

Heeger

D. J.

(1998) Functional magnetic resonance imaging of early visual pathways in dyslexia. Journal of Neuroscience, 18, 6939–6951.

12.

Diamond

Herzberg

(1996) Impaired sensitivity to visual contrast in children treated early and continuously for phenylketonuria. Brain, 119, 523–538.

13.

Dykman

Tone

Dykman

(1997) Analysis of retrospective survey on the effects of nutritional supplements on chronic fatigue syndrome and/or fibromyalgia. Journal of the American Neutraceutical Association, Suppl. 1, 28–31.

14.

Eden

G. F.

Van Meter

J. W.

Rumsey

J. M.

Maisog

J. M.

Woods

R. P.

Zeffrio

T. A.

(1996) Abnormal processing of visual motion in dyslexia revealed by functional brain imaging. Nature, 382, 66–69.

15.

Edwards

V. T.

Hogben

J. H.

Clark

C. D.

Pratt

(1996) Effects of a red background on magnocellular functioning in average and specifically disabled readers. Vision Research, 36, 1037–1045.

16.

Egger

Stolla

McEwen

L. M.

(1992) Controlled trial of hyposensitisation in children with food-induced hyperkinetic syndrome. The Lancet, 339, 1150–1153.

17.

Euri

L. C.

(1989) The development of spelling knowledge and its role in reading acquisition and reading disability. Journal of Learning Disabilities, 22, 356–365.

18.

Evans

B. J.

Busby

Jeanes

Wilkins

A. J.

(1995) Optometric correlates of Meares-Irlen Syndrome: A matched group study. Ophthalmological and Physiological Optics, 15, 481–487.

19.

Evans

B. J.

Patel

Wilkins

Lightstone

Eperjesi

Speedwell

Duffy

(1999) A review of management of 323 consecutive patients seen in a specific learning disabilities clinic. Ophthalmological and Physiological Optics, 19, 454–466.

20.

Fletcher

Martinez

(1994) An eye movement analysis of the effects of scotopic sensitivity correction on parsing and comprehension. Journal of Learning Disabilities, 27(1), 67–70.

21.

Foorman

B. R.

Liberman

B. R.

(1989) Visual and phonological processing of words: A comparison of good and poor readers. Journal of Learning Disabilities, 22, 349–355.

22.

Galaburda

A. M.

(1997) Neurobiology of developmental dyslexia: Results of a ten year research program. Learning Disabilities: A Multidisciplinary Journal, 8(1), 45–50.

23.

Geschwind

Behan

P. O.

(1982) Left-handedness: Association with immune disease, migraine and developmental learning disorder. Proceedings of the National Academy of Sciences of the USA, 79, 5097.

24.

Goodman

A. B.

Pardee

A. B.

(2000) Molecular neurobiological mechanisms in schizophrenia: Seeking a synthesis. Biological Psychiatry, 48, 173–183.

25.

Gray

(1999) Visual perceptual difficulties and reading behavior: Irlen syndrome and eye colour. Unpublished doctor of philosophy thesis, Univer. of Bristol, UK.

26.

Grosser

G. S.

Spafford

C. S.

(1989) Perceptual evidence for and anomalous distribution of rods and cones in the retinas of dyslexics: A new hypothesis. Perceptual and Motor Skills, 68, 683–698.

27.

Grosser

G. S.

Spafford

C. S.

(1990) Light sensitivity in peripheral retinal fields of dyslexic and proficient readers. Perceptual and Motor Skills, 71, 467–477.

28.

Gupta

Vayevegula

(1991) A comprehensive immunological analysis of chronic fatigue syndrome. Scandinavian Journal of Immunology, 33, 319–327.

29.

Hugdahl

(1995) Psychophysiology: The mind-body perspective. Cambridge, MA: Harvard Univer. Press.

30.

Humphries

Kaufmann

W. E.

Galaburda

A. M.

(1990) Developmental dyslexia in women: Neuropathological findings in three cases. Annals of Neurology, 28, 86–95.

31.

Irlen

(1991a) Reading by the colors. New York: Avery.

32.

Irlen

(1991b) Scotopic Sensitivity Syndrome: Screening manual. Long Beach, CA: Perceptual Development Corp.

33.

Irlen

Robinson

G. L.

(1996) The effect of Irlen coloured filters on adult perception of workplace performance: A preliminary survey. Australian Journal of Remedial Education, 1(3), 7–17.

34.

Irvine

J. H.

Irvine

E. W.

(1997) Scotopic Sensitivity Syndrome in a single individual. [a case study] Naval Air Warfare Centre, Weapons Division, China Lake, California, April.

35.

Jeanes

Busby

Martin

Lewis

Stevenson

Pointon

Wilkins

(1997) Prolonged use of coloured overlays for classroom reading. British Journal of Psychology, 88, 531–548.

36.

Knivsberg

(1997) Urine patterns, peptide levels and IgA/IgG antibodies to food proteins in children with dyslexia. Pediatric Rehabilitation, 1(1), 25–33.

37.

Koletzko

(1992) Trans fatty acids may impair biosynthesis of long-chain polyunsaturates and growth in man. Acta Pediatrica, 81, 302–306.

38.

Kubova

Kuba

Peregrin

Novakova

(1996) Visual evoked potenual evidence for a magnocellular system deficit in dyslexia. Physiological Research, 45(1), 87–89.

39.

Kyd

L. J. C.

Sutherland

G. F. M.

McGettrick

R. M.

(1992) A preliminary appraisal of the Irlen screening process for scotopic sensitivity syndrome and the effect of Irlen coloured overlays on reading. The British Orthoptic Journal, 49, 25–30.

40.

Legein

C. P.

Bouma

(1982) Reading and the ophthalmologist. Documenta Ophthalmologica, 53, 123–157.

41.

Lehmkuhle

Garzia

R. P.

Turner

Hash

Baro

J. A.

(1993) A defective visual pathway in children with reading disability. New England Journal of Medicine, 328, 989–996.

42.

Liohtstone

Lightstone

Wilkins

(1999) Both coloured overlays and coloured lenses can improve reading fluency, but their optimal chromaticities differ. Ophthalmological and Physiological Optics, 19, 297–304.

43.

Livingstone

M. S.

Rosen

G. D.

Drislane

F. W.

Galaburda

A. M.

(1991) Physiological and anatomical evidence for a magnocellular defect in developmental dyslexia. Proceedings of the National Academy of Science USA. 88, 7943–7947.

44.

Makrides

Neumann

Summer

Pater

Gibson

(1995) Are long-chain polyunsaturated fatty acids essential nutrients in infancy? The Lancet, 345, 1463–1468.

45.

McCrone

(1998) Investigating the causes of autism. New Scientist, 20 June, 43–45.

46.

McGregor

N. R.

Dunstan

R. H.

Butt

H. L.

Roberts

T. K.

Klineberg

I. J.

Zerbes

(1997) A preliminary assessment of the association between SCC-90R psychological inventory responses with changes in urinary metabolites in patients with Chronic Fatigue Syndrome. Journal of Chronic Fatigue Syndrome, 3(1), 17–37.

47.

McGregor

N. R.

Dunstan

R. H.

Zerbes

Butt

H. L.

Roberts

T. K.

Klineberg

I. J.

(1996a) Preliminary determination of the association between symptom expression and urinary metabolites in subjects with Chronic Fatigue Syndrome. Biochemical and Molecular Medicine, 58, 85–92.

48.

McGregor

N. R.

Dunstan

R. H.

Zerbes

Butt

H. L.

Roberts

T. K.

Klineberg

I. J.

(1996b) Preliminary determination of a molecular basis to Chronic Fatigue Syndrome. Biochemical and Molecular Medicine, 57, 73–80.

49.

Meares

(1980) Figure/ground, brightness, contrast and reading disabilities. Visible Language, 14, 13–29.

50.

Ojo-Amaize

E. A.

Conley

E. J.

Peter

J. B.

(1994) Decreased natural killer cell activity is associated with severity of chronic fatigue immune dysfunction syndrome. Clinical Infectious Diseases, 18(Suppl.), 157–159.

51.

Pennington

B. E.

(1989) Using genetics to understand dyslexia. Annals of Dyslexia, 39, 81–91.

52.

Potaznik

Kozol

(1992) The incidence of ocular disturbances in people with chronic fatigue syndrome. Optometry and Vision Science, 10, 811–814.

53.

Qavi

H. B.

Green

M. T.

Lusso

Pearson

Ablashi

D. V.

(1996) Morphological and ultrastructural changes induced in corneal epithelial cells by HIV-1 and HHV-6 in vitro. Current Eye Research, 15, 597–604.

54.

Rae

Lee

M. A.

Dixon

R. M.

Blamire

R. M.

Thompson

C. H.

Styles

Talcott

Richardson

Stein

(1998) Metabolic anomalies in developmental dyslexia detected by 1H magnetic resonance spectroscopy. The Lancet, 351, 1849–1852.

55.

Richardson

A. J.

Cox

I. J.

Sargentoni

Puri

B. K.

(1997) Abnormal cerebral phospholipid metabolism in dyslexia indicated by phosphorus-31 magnetic resonance spectroscopy. Nuclear Magnetic Resonance in Biomedicine, 10, 309–314.

56.

Riding

R. J.

Pugh

J. C.

(1977) Iconic memory and reading performance in nine year old children. British Journal of Educational Psychology, 47, 132–137.

57.

Robinson

G. L.

Conway

R. N. F.

(1994) Irlen filters and reading strategies: Effect of coloured filters on reading achievement, specific reading strategies and perception of ability. Perceptual and Motor Skills, 79, 467–483.

58.

Robinson

G. L.

Conway

R. N. F.

(2000) Irlen lenses and adults: A small scale study of reading speed, accuracy, comprehension, and self-image Australian Journal of Learning Disabilities, 5, 4–13.

59.

Robinson

G. L.

Foreman

P. J.

(1999a) The effect of Irlen coloured filters on eye movement. Behavioural Optometry, 7(4), 5–18.

60.

Robinson

G. L.

Foreman

P. J.

(1999b) Scotopic Sensitivity/Irlen Syndrome and the use of coloured filters: A long-term placebo controlled and masked study of reading achievement and perception of ability. Perceptual and Motor Skills, 89, 83–113.

61.

Robinson

G. L.

Hopkins

Davies

(1995) The incidence of Scotopic Sensitivity Syndrome in secondary school populations: A preliminary survey. The Bulletin for Learning Disabilities, 5(1), 36–56.

62.

Robinson

G. L.

Roberts

T. K.

McGregor

N. R.

Dunstan

R. H.

Butt

(1999) Understanding the causal mechanisms of visual processing problems: A possible biochemical basis for Irlen Syndrome? Australian Journal of Learning Disabilities, 4(4), 21–29.

63.

Rosenhall

Johannson

Orndahl

(1987) Eye motility dysfunction in chronic primary fibromyalgia with dysesthenia. Scandinavian Journal of Rehabilitation Medicine, 19, 139–145.

64.

Rosenhall

Johannson

Orndahl

(1996) Otoneurological and audiologic findings in fibromyalgia. Scandinavian Journal of Rehabilitation Medicine, 28, 225–232.

65.

Salmelin

Service

Kiesiliä

Vutela

Salonen

(1996) Impaired visual word processing in dyslexia revealed with magnetoencephalography. Annals of Neurology, 40, 157–162.

66.

Shapiro

K. L.

Raymond

J. E.

Arnell

K. M.

(1994) Attention to visual pattern information produces the attentional blink in rapid serial visual presentations. Journal of Experimental Psychology: Human Perception and Performance, 20, 357–371.

67.

Singh

V. K.

Lin

S. X.

Yang

V. C.

(1998) Serological association of measles virus and human herpes virus-6 with brain autoantibodies in autism. Clinical Immunology and Immunopathology, 89(1), 105–108.

68.

Solan

H. A.

Ficarra

Brannan

J. R.

Rucker

, (1998) Eye movement efficiency in normal and reading disabled elementary school children: Effects of varying luminance and wavelength. Journal of the American Optometric Association, 69, 455–464.

69.

Solman

R. T.

Cho

Dain

S. J.

(1992) Colour mediated grouping effects in good and disabled readers. Ophthalmological and Physiological Optics, 11, 320–327.

70.

Solman

R. T.

Dain

S. J.

Keech

S. L.

(1991) Color-mediated contrast sensitivity in disabled readers. Optometry and Vision Science, 68, 331–337.

71.

Spafford

C. S.

Grosser

G. S.

(1991) Retinal differences in light sensitivity between dyslexic and proficient reading children: New prospects for Optometric input in diagnosing dyslexia. Journal of the American Optometric Association, 62, 610–615.

72.

Stein

Fowler

(1985) Effect of monocular occlusion on visuomotor perception and reading in dyslexic children. The Lancet, 2, 67–73.

73.

Stein

Talcott

(1999) Impaired neuronal timing in developmental dyslexia: The magnocellular hypothesis. Dyslexia, 5, 55–77.

74.

Stevens

L. J.

Zentall

S. S.

Abate

M. L.

Kuczek

Burgess

J. R.

(1996) Omega-3 fatty acids in boys with behavior, learning and health problems. Physiology and Behavior, 59, 915–920.

75.

Stevens

L. J.

Zentall

S. S.

Abate

M. L.

Watkins

B. A.

Lipp

S. R.

Burcess

J. R.

(1995) Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. American Journal of Clinical Nutrition, 62, 761–768.

76.

Storoy

B. J.

(1995) Benefits of docosahexaenioc acid supplements to dark adaptation in dyslexies. The Lancet, 346, 385.

77.

Stordy

B. J.

(1998) Dyslexia, attention deficit hyperactivity disorder, dyspraxia: Do fatty acids help? Dyslexia Review, 9(2), 3–6.

78.

Suhadolnik

R. J.

Peterson

D. L.

O'Brien

Cheney

P. R.

Herst

C. V.

Reichenbach

N. L.

Kon

Horvath

B. E.

Iacono

K. T.

Adelson

M. E.

De Meirleir

De Becker

Charubala

Pfleiderer

(1997) Biochemical evidence for a novel low molecular weight 2–5A-dependent RNase L in chronic fatigue syndrome. Journal of Interferon and Cytokine Research, 17, 377–385.

79.

Suhadolnik

R. J.

Reichenbach

N. L.

Hitzges

Sobol

R. W.

Peterson

D. L.

Henry

Ablashi

D. V.

Muller

W. E.

Schroder

H. C.

Carter

W. A.

(1994) Upregulation of the 2–5A Synthetase/RNase L pathway associated with chronic fatigue syndrome. Clinical Infectious Diseases, 18, S96–-S104.

80.

Torgesen

J. K.

(1998) Learning disabilities: An historical and conceptual overview. In Wong

(Ed.), Learning about learning disabilities. San Diego, CA: Academic Press. 3–34.

81.

Tyrrell

Holland

Dennis

Wilkins

(1995) Coloured overlays, visual discomfort, visual search and classroom reading. Research in Reading, 18, 10–23.

82.

Vedelago

L. J.

(1994) Visual dysfunction in chronic fatigue syndrome: Behavioral Optometric assessment and management. Behavioral Optometry, 5(4), 11–18.

83.

Wannermacher

R. W.

Jr. Klainer

A. S.

Dinterman

R. E.

Beisel

W. R.

(1976) The significance and mechanism of an increased serum phenylalanine-tyrosine ratio during infection. American Journal of Clinical Nutrition, 29, 997–1006.

84.

Whiting

Robinson

G. L.

Parrot

C. E.

(1994) Irlen coloured filters for reading: A clinical study. Australian Journal of Remedial Education, 26(3), 13–19.

85.

Wilkins

A. J.

(1997) A system of precision ophthalmic tinting and its role in the treatment of visual stress. In Dickinson

C. M.

Murray

I. J.

Carden

(Eds.), John Dalton's colour vision legacy. London: Taylor & Francis. 695–708.

86.

Wilkins

A. J.

Evans

B. J. W.

Brown

J. A.

Busby

A. E.

Wingfield

A. E.

Jeans

R. J.

Bald

(1994) Double-masked placebo-controlled trial of precision spectral filters in children who use coloured overlays. Ophthalmological and Physiological Optics, 14, 365–370.

87.

Wilkins

A. J.

Jeans

R. J.

Pumfrey

P. D.

Laskier

(1996) Rate of reading test: Its reliability and its validity in the assessment of the effects of coloured overlays. Ophthalmological and Physiological Optics, 16, 491–497.

88.

Wilkjns

A. J.

Lewis

(1999) Coloured overlays, text and texture. Perception, 28, 641–650.

89.

Williams

M. C.

Lecluyse

Rock-Faucheux

(1992) Effective interventions for reading disability. Journal of the American Optometric Association, 63, 411–417.

90.

Williams

M. C.

Lovegrove

W. J.

(1992) Sensory and perceptual processing in reading disability. In Brannan

(Ed.), Application of parallel processing in vision. Amsterdam: Elsevier Science. 263–302.

91.

Willows

D. M.

(1998) Visual processing in learning disabilities. In Wong

(Ed.), Learning about learning disabilities. (2nd ed.) New York: Academic Press. 163–193.

92.

Wood

L. A.

Cooperd

D. S.

(1992) Autoimmune thyroid disease, left handedness and developmental dyslexia. Psychoneuroendocrinology, 17, 95–99.