28 male Long-Evans rats prepared with lesions of the middle cerebral artery displayed deficits in spatial navigational learning in a simple version of the Morris Water Maze task not seen in animals prepared with the same injury but administered 4 treatments with topiramate after surgery.
Get full access to this article
View all access options for this article.
References
1.
GoldbergJ. F.BurdickM. A. (2001) Cognitive side effects of anticonvulsants. Journal of Clinical Psychiatry, 62, 27–33.
2.
McDanielW. F.FjordbakT.SchmidtM. S.TuckerJ. C.DavisB. K. (1991) The behavioral effects of bilateral middle cerebral artery hemorrhagic ischemia in rat. NeuroReport, 2, 669–702.
3.
TuckerJ. C.McDanielW. F.SmithS. R. (1992) A behavioral study of bilateral middle cerebral artery hemorrhagic ischemia in rats. NeuroReport, 3, 725–728.
4.
YangY.ShuaibA.LiQ.ShiddiquiM. M. (1998) Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolization. Brain Research, 804, 169–176.
