Three groups of animals, a 15 ECS group (N of 9), a 15 ether-ECS group (N of 11), and a control group (N of 9) were exposed to a series of “timidity box” tests 27, 75, 110, and 163 days after last ECS. The “timidity box” was found to provide a sensitive measure of relatively long lasting emotional changes as a function of the series of 15 ECS. The ECS group proved to be more “timid” than the control group. The ether-ECS animals in this experiment exhibited minimal convulsions and evidenced changes in behavior similar to those seen by the ECS group. The degree of significance of differences tended to decrease as the post-ECS time increased, i. e., the “timid” behavior induced by ECS decreased as a function of time.
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