Locomotor activity and performance on several different learning tasks were measured in mice genetically selected for high brain weight and in unselected control lines. Brain size was found to be positively related to locomotor activity in an open field and to performance on brightness discrimination-learning and active avoidance tasks and negatively related to passive avoidance performance. The results provide support for the findings of a previous study on these animals and add further information on the nature of the brain size and behavior relationship.
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