The nature of schizophrenia has long been debated. The purpose of the present study was to investigate the hypothesis that typical/atypical schizophrenia (process/reactive) entails dysfunctioning in the frontal and temporal areas of the brain respectively. Rather than the conventional method of group mean analysis, the inverse factor analytic procedure of profile analysis was used to isolate clusters of individual profiles whose performance over 53 neuropsychological variables was similar. Results did not substantiate this hypothesis but did suggest a possible brain-damage component in typical schizophrenics which was not present in atypical schizophrenics. These results represent the first time that a process/reactive continuum has been suggested from an inductive approach for analyzing the performance of schizophrenics on an extensive battery of psychological tests sensitive to brain damage.
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