Towards Understanding Carcinogenic Hazards: A Crisis in Paradigms

1. Ames, B.N. , Durston, W.E. , Yamasaki, E. , and Lee, F. D. (1973). Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. 70, 2281–2285.

2. Trosko, J.E. , Jone, C. , and Chang, C. C. (1983). The role of tumor promoters on phenotypic alterations affecting intercellular communication and tumorigenesis. Ann N. Y. Acad. Sci. 407, 316–327.

3. Trosko, J.E. , and Chang, C. C. (1985). Implications for risk assessment of genotoxic and non-genotoxic mechanisms in carcinogenesis. In: Vouk, B.V. , Butler, G.C. , Hoel, D.G. , and Peakall, D.B. , eds. Methods for Estimating Risks of Chemical Injury: Human and Non-Human Biota and Ecosystems. Chichester, England: John Wiley and Sons, pp. 181–200.

4. Trosko, J.E. , and Chang, C. C. (1983). Potential role of intercellular communication in the rate-limiting step in carcinogenesis. In: Cimino, J. A. , ed. Cancer and the Environment: Possible Mechanisms of Thresholds for Carcinogens and Other Toxic Substances. New York: Mary Ann Liebert, pp. 5–21,

5. Tennant, R.W. , Margolin, B.H. , Shelby, M.D. , Zeigler, E., Huseman, J.K., Spalding, J., Caspary, W., Resnick, M., Stasiewicz, S., Anderson, B., and Minor, R. (1987). Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 236, 933–941.

6. Boutwell, R.K. (1974). The function and mechanism of promoters of carcinogenesis. Crc Crit. Rev. Toxicol. 2, 419–443.

7. Pitot, H.C. , Goldsworthy, T. , and Moran, S. (1981). The natural history of carcinogenesis: Implication of experimental carcinogenesis in the genesis of human cancer. J. Supramol. Struct. Cell. Biochem. 17, 133–146.

8. Markert, C. (1968). Neoplasia: A disease of cell differentiation. Cancer Res. 28, 1908–1914.

9. Pierce, G.B. ,(1980). Neoplasms, differentiation and mutations. Am. J. Pathol. 77, 103–118.

10. Potter, V.R. (1978). Phenotypic diversity in experimental hepatomas: The concept of partially blocked ontogeny. Br. J. Cancer 38, 1–23.

11. Trosko, J.E. , Riccardi, V.M. , Chang, C.C. , Warren, S. , and Wade, M. (1985). Genetic predispositions to initiation or promotion phases in human carcinogenesis. In: Anton-Guirgis, H. , and Lynch, H.T. eds. Biomarkers. Genetics and Cancer. New York: Rheinhold. pp. 13–37

12. Potter, V.R. (1983). Cancer as a problem in intercellular communication: Regulation by growth-inhibiting factors (chalones). Progr. Nucleic Acid Res. Mol. Biol. 29, 161–173.

13. Madhukar, B.V. , Trosko, J.E. , and Chang, C. C. (1989). Chemical, oncogene, and growth factor modulation of gap junctional communication in carcinogenesis. In: Sperelakis, N. , and Cole, W.C. , eds. 1. Boca Raton, Fl: Crc Press, pp. 144–157.

14. Yuspa, S.H. , and Morgan, D. L. (1981). Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis. Nature 293, 72–74.

15. Kawamura, H. , Strickland, J.E. , and Yuspa, S. A. (1985). Association of resistance to terminal differentiation with initiated of carcinogenesis in adult mouse epidermal cells. Cancer Res 45, 2748–2752.

16. Scott, R.E. , and Maercklein, P. B. (1985). An initiator of carcinogenesis selectively and stably inhibits stem cell differentiation: A concept that initiation of carcinogenesis involves multiple phases. Proc. Natl. Acad. Sci. Usa. 82, 2995–2999,

17. Trosko, J.E. , and Chang, C. C. (1988). Chemical and oncogene modulation of gap junctional intercellular communication. In: Langenback, R. , and Elmore E. , eds. 1. New York: Raven Press, pp. 97–116.

18. Trosko, J.E. , and Chang, C. C. (1978). Environmental carcinogenesis: An integrative model. Q. Rev. Biol. 53, 115–141.

19. Trosko, J.E. , and Chang, C. C. (1983). The role of Dna repair capacity and somatic mutations in carcinogenesis and aging. In: Blumenthal, A. T. , ed. Handbook of Diseases of Aging. New York; Van Nostrand, Rheinhold. pp. 252–295

20. Williams, G. , and Weisburger, J. H. (1986). Chemical carcinogens. In: Klaassen, C.D. , Amdur, M.O. , and Doull, J. , eds. Toxicology, 3rd ed. New York: Macmillan, pp. 99–173.

21. Tsuda, H. , Sakata, T. , Masui, T. , Imaida, K. , and Ito, N. (1984). Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxy-ethylnitrosamine. Carcinogenesis 5, 525–531.

22. Williams, G.M. (1984). Modulation of chemical carcinogenesis by xenobiotics. Fund. Appl. Toxicol. 4, 325–344.

23. Manson, M.M. , Green, J.A. , and Driver, H. E. (1987). Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B1. Carcinogenesis 8, 723–728.

24. Shirai, T. , Tsuda, H. , Ogiso, T. , Hirose, M. , and Ito, N. (1987). Organ specific modifying potential of ethinyl estradiol on carcinogens. Carcinogenesis 8, 115–119.

25. Klein, G. , and Klein, E. (1984). Oncogene activation and tumor progression. Carcinogenesis 5, 429–435.

26. Weinberg, R.A. (1985). The action on oncogenes in the cytoplasm and nucleus. Science 230, 770–776.

27. Goyns, M.H. (1986). The role of oncogenes in human cancer. Ca 1, 183–190.

28. Marshall, C.J. (1986). Oncogenes. J. Cell Sci. 4, 417–430.

29. Nishimura, S. , and Sekiya, T. (1987). Human cancer and cellular oncogenes. Biochem. J. 243, 313–327.

30. Trosko, J.E. (1984). A new paradigm is needed in toxicology evaluation. Environ. Mutagen. 6, 767–769.

31. Clive, D. (1987). Genetic toxicology: From theory to practice. J Clin. Res. Drug Dev. 1, 11–41.

32. Trosko, J.E. , Chang, C.C. , and Medcalf, A. (1983). Mechanisms of tumor promotion: Potential role of intercellular communication. Cancer Invest. 1, 511–526.

33. Potter, V.R. (1980). Initiation and promotion in cancer formation: The importance of studies on intercellular communication. Yale J. Biol. Med. 53, 367–384.

34. Trosko, J.E. , Chang, C.C. , and Wade, M. H. (1984). Mammalian mutagenesis. In: Chopra, V.L. , Joshi, B.C. , Sharma, R.P. , and Bansal, H.C. , eds. Genetics: New Frontiers, Vol. 1. New Delhi: Oxford & Ibh Publ. Co., pp. 329–346

35. Trosko, J.E. , and Chang, C. C. (1980). An integrative hypothesis linking cancer, diabetes, and atherosclerosis: The role of mutations and epigenetic changes. Med. Hypotheses 6, 455–468.

36. Majesky, M.W. , Reidy, M.A. , Benditt, E.P. , and Juchau, M. R. (1985). Focal smooth muscle proliferation in the aortic intima produced by an initiation-promotion sequence. Proc. Natl. Acad. Sci. Usa 82, 3450–3454.

37. Trosko, J.E. , Chang, C.C. , Madhukar, B.V. , Oh, S.Y. , Bombick, D. , and El- Fouly, M. H. (1988). Modulation of gap junction intercellular communication by tumor promoting chemicals, oncogenes and growth factors during carcinogenesis. In: Hertzberg, E. , and Johnson, R. , eds. 1. New York: Alan R. Liss, pp. 435–448.

38. Nicolson, G.L. (1987). Tumor cell instability, diversity, and progression to the metastatic phenotype: From oncogene to oncofetal expression. Cancer Res. 47, 1473–1487.

39. Borek, C. , and Sachs, L. (1966) The difference in contact inhibition of cell replication between normal cells and cells transformed by diferent carcinogens. Proc. Natl. Acad. Sci. Usa 56, 1705–1711.

40. Corsaro, C.M. , and Migeon, B. R. (1977). Comparison by contact-mediated communication in normal and transformed human cells in culture. Proc. Natl. Acad. Sci. U.S.A. 74, 4476–4480.

41. Abercrombie, M. (1979). Contact inhibition and malignancy. Nature 281, 259–262.

42. Iijama, N. , Yamamoto, T. , Inoue, K. , Soo, S. and Matsuzawa, A. (1969). Experimental studies on dynamic behavior of cells in subcutaneous solid tumor. Jpn. J. Exp. Med. 39, 205–221.

43. Hamada, J. , Takeichi, N. , and Kobayashi, H. (1987). Inverse correlation between the metastatic capacity of cell clones derived from a rat mammary carcinoma and their intercellular communication with normal fibroblasts. Jpn. J. Cancer Res. 78, 1175–1178.

44. Nicholson, G.L. , Dulski, K.M. , and Trosko, J. E. (1988). Loss of intercellular junctional communication correlates with metastatic potential in mammary adenocarcinoma cells. Proc. Natl. Acad. Sci U.S.A. 85, 473–476.

45. Kanno, Y. (1985). Modulation of cell communication and carcinogenesis. Jpn. J. Phyiol. 35, 693–707.

46. Yamasaki, H. , Hollstein, M. , Mesnil, M. , Martel, N. , and Aguelon, A.-M. (1987). Selective lack of intercellular communication between transformed and nontransformed cells as a common property of chemical and oncogene transformation of Balb/c3T3 cells. Cancer Res. 47, 5658–5664.

47. Enomoto, T. , and Yamasaki, H. (1984). Lack of intercellular communication between chemically transformed and surrounding nontransformed Balb/c3T3 cells. Cancer Res. 44, 5200–5203.

48. Trosko, J.E. , and Chang, C. C. (1988). Non-genotoxic mechanisms in carcinogenesis: Role of inhibited intercellular communication. In: Hart, R. , and Hoerger, F.D. , eds. Banbury Report, Cold Spring Harbor Laboratory, Cold Spring Harbor, Ny, pp. 139–174

49. Yamasaki, H. (1984). Modulation of cell differentiation by tumor promoters. In: Slaga, T. J. , ed. Mechanisms of Tumor Promotion, Vol. Iv. Boca Raton. Fl: Crc Press, pp. 1–26

50. Chang, C.C. , Trosko, J.E. , Kung, H.J. , Bombick, D. , and Matsumura, F. (1985). Potential role of the src gene product in inhibiting of gap junctional communication in Nih 3T3 cells. Proc. Natl. Acad. Sci. U.S. A. 82, 5360–5364.

51. Atkinson, M.M. , Anderson, S.K. , and Sheridan, J. D. (1986). Modification of gap junctions in cells transformed by a temperature-sensitive mutant of Rous sarcoma virus. J. Membrane Biol. 9, 53–64.

52. Azarnia, R. , and Loewenstein, W. R. (1984). Intercellular communication and the control of growth: Alteration of junctional permeability by the src gene: A study with a temperature-sensitive mutant Rous sarcoma virus. J. Membrane Biol. 82, 191–205.

53. El-Fouly, M.H. , Warren, S.T. , Trosko, J.E. , and Chang, C. C. (1986). Inhibition of gap junctional-mediated intercellular communication in cells transfected with the human H-ras oncogene. Am. J. Hum. Genet. 39. A30.

54. Azarnia, R. , Reddy, S. , Kmiecik, T.E. , Shalloway, D. , and Loewenstein, W. R. (1988). The cellular src gene product regulates junctional cell-to-cell communication. Science 239, 398–400.

55. Atkinson, M. , and Sheridan, J. (1984). Decreased junctional permeability in cells transformed by 3 different viral oncogenes: A quantitative video analysis. J. Cell. Biol. 99. 401a.

56. Azarnia, R. , and Loewenstein, W. R. (1987). Polyomavirus middle T antigen down regulates junctional cell to cell communication. Mol. Cell Biol. 7, 946–950.

57. Ohlsson, R.I. , and Pfeifer- Ohlsson, S. B. (1987). Cancer genes, proto-oncogenes. and development Exp. Cell Res. 173, 1–16.

58. Glaichenhaus, N. , and Vasseur, M. (1987). Proto-oncogenes and differentiation. Ca 1, 255–257.

59. Madhukar, B.V. , Oh, S.Y. , Chang, C.C. , Wade, M. , and Trosko, J. E. (1989). Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-B. and peptide hormones in normal human keratinocytes Carcinogenesia 10, 13–20,

60. Sporn, M.B. , Roberts, A.B. , Wakefield, L.M. , and Assoian, R. K. (1986). Transforming growth factor-β: Biological function and chemical structure. Science 233, 532–534.

61. Trosko, J.E. , Chang, C.C. , and Netzloff, M. (1982). The role of inhibited cell-cell communication in teratogenesis. Teratogenesis Carcinog. Mutagen. 2, 31–45.

62. Yotti, L.P. , Chang, C.C. , and Trosko, J. E. (1979). Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter. Science 208, 1089–1091.

63. Ye, Y.X., Bombick, D., Hirst, K., Zhang, G., Madhukar, B.V., Chang, C.C., Trosko, J.E., and Akera, T. The effect of gossypol on cytotoxicity, mutagenicity and the modulation of gap junctional communication in various mammalian cell lines in vitro. Submitted for publication.

64. Fletcher, W.H. , Shiu, W.W. , Ishida, T. , Haviland, D.L. , and Ware, C. F. (1987). Resistance to the cytolytic action of lymphotoxin and tumor necrosis factor coincides with the presence of gap junctions uniting target cells. J. Immunol. 139, 956–962.

65. Trosko, J.E. , Jone, C. , and Chang, C. C. (1987). Inhibition of gap junctional-mediated intercellular communication in vitro by aldrin, dieldrin and toxaphene: A possible cellular mechanism for their tumor-promoting and neurotoxic effects. Mol. Toxicol. 1, 83–93.

66. Neyton, J. , and Trautmann, A. (1986). Acetylcholine modulation of the conductance of intercellular junctions between rat lacrimal cells. J. Physiol. 377, 283–295.

67. Chen, T.H. , Kavanagh, T.J. , Chang, C.C. , and Trosko, J. E. (1984). Inhibition of metabolic cooperation in Chinese hamster V79 cells by various organic solvents and simple compounds. Cell Biol. Toxicol. 1, 155–171.

68. Trosko, J.E. , and Horrobin, D. F. (1980). The activity of diazepam in a Chinese hamster V79 lung cell assay for tumor promoters. Ircs Med. Sci. 8, 887.

69. Jone, C.M. , Parker, L. , Trosko, J.E. , Netzloff, M. , and Chang, C. C. (1986). Inhibition of metabolic cooperation by the anticonvulsants, diphenylhydantoin and phenobarbital. Teratogenesis Carcinog. Mutagen. 5, 379–391.

70. Verma, A.K. , and Boutwell, R. K. (1980). Effects of dose and duration of treatment with the tumor-promoting agent, Tpa. on mouse skin carcinogenesis. Carcinogenesis 1, 271–276.

71. Goldsworthy, T. , Campbell, H. , and Pitot, H. C. (1984). The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration. Carcinogenesis 5, 67–71.

72. Deml, E. and Oesterle, D. (1987). Dose-response of promotion by polychlorinated biphenyls and chloroform in rat liver foci bioassay. Arch. Toxicol. 60, 209–211.

73. Ito, N. , Fukushima, S. , Tamano, S. , Horose, M. , and Hagiwara, A. (1986). Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats. J. Natl. Cancer Inst. 77, 1261–1265.

74. Zeiger, E. , and Haworth, S. (1985). Tests with a preincubation modification of the Salmonella/microsome assay. Progr. Mutat. Res. 5, 187–199.

75. Venitt, S. (1985). Summary report on the performance of the bacterial mutation assays. Prog. Mutat. Res. 5, 11–23,

76. Mcgregor, D.B. , and Prentice, R. D. (1985). Phenobarbital: Its mutagenicity and toxicity in the Ames Salmonella test. Prog. Mutat. Res. 5, 741–743.

77. Rexroat, M.A. , and Probst, G. S. (1985). Mutation tests with Salmonella using the plate-incorporation assay. Prog. Mutat. Res. 5, 201.

78. Klaunig, J.A. , and Ruch, R. J. (1987). Role of cyclic Amp in the inhibition of mouse hepatocytes intercellular communication by liver tumor promoters. Toxicol. Appl. Pharmacol. 91, 159–170.

79. Clemmensen, J. , and Hjalgrim- Jensen, S. (1987). Does phenobarbital cause intracranial tumors? A follow-up through 35 years. Ecotoxicol. Environ. Safety 5, 255–260.

80. Hill, R.M. , Verniaud, W.M. , Horning, M.G. , Mcculley, L.B. , and Morgan, N. F. (1974). Infants exposed in utero to antiepileptic drugs: A prospective study. Am. J. Dis. Child. 127, 645–652.