Modernization of Nose-Only Smoking Machines for Use in Animal Inhalation Studies

Abstract

Several modifications to a continuous-smoking inhalation machine for exposing animals to cigarette smoke are described. The improvements to the original machine provide a much more efficient method of exposing animals to cigarette smoke, and improve substantially the simplicity of operation and maintenance. The changes include a simplified pump for extracting puffs from the cigarettes, computerized control and display of exposure conditions, improved structure of the cigarette holders, and addition of a second puffing port to allow preignition of the cigarettes. The modifications were part of an overall modernization of the original design, as well as to allow the use of cigarettes which do not decrease in length as they are smoked (cigarettes which heat rather than burn tobacco).

References

1. Baumgartner, H. , and Coggins, C.R.E. (1980). Description of a continuous-smoking inhalation machine for exposing small animals to tobacco smoke. Beiträge Tabakforsch. Int. 10, 169–174.

2. Briggs, C.D. , Mccready, J. , and Schweitzer, A. (1980). The chemical evaluation of a continuous-smoking inhalation machine. Beiträge Tabakforsch. Int. 10, 175–184.

3. Coggins, C.R.E. , Lam, R. , and Morgan, K.T. (1982). Life-time inhalation study in rats, using cigarettes containing different amounts of Cyuel tobacco supplement. Toxicology 22, 287–296.

4. Ringrose, A.R. , Crawley, F.E.H. , and Coggins, C.R.E. (1984). An automatic device for the addition of precise amounts of radiolabel to cigarettes. Beiträge Tabakforsch. Int. 12, 117–121.

5. Coggins, C.R.E. , Ayres, P.H. , Mosberg, A.T. , Sagartz, J.W. , Burger, G.T. , and Hayes, A.W. (1989). Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that bum tobacco. Fund. Appl. Toxicol. 13, 460–483.

6. Coggins, C.R.E. , Ayres, P.H. , Mosberg, A.T. , Burger, G.T. , Sagartz, J.W. , and Hayes, A.W. (1989). Comparative inhalation study in rats, using a second prototype of a cigarette that heats rather than bums tobacco. Inhal. Toxicol. 1, 197–226.