Application of the Principles of Total Quality Will Improve Science and Compliance

Abstract

The scientific method was developed over a long period of time by many scientists from different disciplines. The procedure starts with an observation and the defining of a problem. This lead to postulating a hypothesis, conducting an experiment, and formulating a theory. The theory is then retested. Good Laboratory Practice (GLP) compliance was the first imposition of quality on top of the normal science process. To date, this improved compliance has contributed to documentation of science, but it has not done much to improve science itself. By learning and practicing the principles of total quality, both science and compliance can improve. The result of using the total quality principles is conducting toxicology studies right the first time. This goes beyond the GLPs and is not in opposition to them. Total quality requires planning, proper project execution, unbiased analysis of data, and reviewing and improving the process by capturing the good points and improving the weak ones. This process is very similar to the scientific method and consistent with good science. To use these principles in the management of a toxicology study, we must be good communicators and develop a common understanding with all professionals involved.

References

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