Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA)

Abstract

Objective

To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes.

Research design and methods

In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy.

Results

After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident.

Conclusion

The lack of association between NMR-defined lipoproteins and DR does not support clinical use of NMR spectroscopy for management of patients with DR.

Keywords

diabetic retinopathy NMR-lipoprotein retinal photography type 2 diabetes

References

1. Keech AC , Mitchell P , Summanen PA et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet 2007;370:1687–97.

2. Dodson PM. Diabetic retinopathy: treatment and prevention. Diabetes Vasc Dis Res 2007;4(suppl 3):S9–S11; doi:10.3132/dvdr.2007.051.

3. de Boer IH , Astor BC , Kramer H et al. Mild elevations of urine albumin excretion are associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2008;197:407–14.

4. Ding SY , Tigno XT , Hansen BC. Nuclear magnetic resonance-determined lipoprotein abnormalities in nonhuman primates with the metabolic syndrome and type 2 diabetes mellitus. Metabolism 2007;56:838–46.

5. Jenkins AJ , Lyons TJ , Zheng D et al. Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort: associations with gender and glycemia. Diabetes Care 2003;26:810–18.

6. Bild D , Bluemke D. The Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol 2002;156:871–81.

7. Wong TY , Klein R , Islam FM et al. Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol 2006;141:446–55.

8. Group DRSR. Design, methods and baseline results: A modification of the Airlie House Classification of diabetic retinopathy. Prepared by the Diabetic Retinopathy Study Group. Invest Ophthalmol Vis Sci 1981;21 (DRS Report 7):1b–22b.

9. Festa A , Williams K , Hanley AJ et al. Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study. Circulation 2005;111:3465–72.

10.

10. Mora S , Szklo M , Otvos JD et al. LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2007;192:211–17.