Abstract
In a recent study of the action of various diuretics in uranium nephritis, 2 it was shown that the anesthetic employed in the experiments not only influenced the output of urine, but that following the anesthetic, diuretic substances such as caffeine, theobromine, and 0.9 per cent. sodium chloride lost their diuretic value.
The following experiments are being conducted to ascertain if the previously mentioned anesthetics have any effect in reducing the output and in changing the composition of the urine in the normal dog and if the anesthetics differ from one another in their action.
When full grown dogs are given Gréhant's anesthetic in the strength usually employed there is a marked reduction in the output of urine and the animal becomes glycosuric, the percentage of glucose varying between 0.165-3.33 per cent. Acetone has so far been constantly present in the urine of these full-grown animals.
An albuminuria is induced and is accompanied by the appearance of casts, hyaline, or hyaline and granular. In one of the animals bile appeared in the urine on the second day after recovery from the anesthetic and persisted for two days.
The anesthesia is complete for from ten to eighteen hours. Three animals have failed to recover.
When Grhants anesthetic is given to full-grown dogs in half the strength usually employed the output of urine is usually but slightly diminished, the animals however become glycosuric, the percentage of glucose having varied between .101-.301 per cent. The urine does not contain acetone.
Albumen is present with hyaline or hyaline and granular casts.
The anesthesia is imperfect. Recovery is usually complete within twelve hours.
In a final series of animals, puppies were used. The age of these animals ranged from six weeks to four and a half months.
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