Effect of Dietary Cholic Acid on in vivo Cholesterol Metabolism. ∗

Summary

1. Dietary cholic acid reduced the rate of in vivo hepatic cholesterol synthesis within 3 days, as indicated by incorporated acetate-1-C¹⁴. 2. Continued feeding of cholic acid produced no further decrease in hepatic cholesterol synthesis rate over the 21-day period. 3. Increased serum bile acid level correlated with decreased liver cholesterol synthesis rates at all time intervals. 4. There was a small but significant increase in liver cholesterol concentration caused by dietary cholic acid. This increase remained constant throughout the experimental period. 5. Dietary cholic acid had no effect on in vivo kidney and intestine cholesterol synthesis rates.