Effects of Immunized Parental Strain Bone Marrow on Lethally Irradiated F 1 Hybrid Mice

Summary

Pre-sensitization of parental strain donor mice against F₁ hybrid recipients accentuated the foreign bone marrow reaction caused by injection of parental marrow cells into lethally irradiated F₁ recipients. This effect occurred with use of parental strains (101 and C3H) that were histocompatible at the H-2 locus, as well as with those (C57BL and 101) that were histoincompatible at this locus. These results are interpreted to indicate the importance of relative antibody-forming potency of implanted cells, as well as the extent of histocompatibility differences in pathogenesis of the homograft reaction.