Abstract
Summary
Distribution of 5-hydroxytryptamine (HT) in various cytoplasmic fractions of rat brain has been determined, and the neurohumor was confined almost exclusively to the mitochondrial fraction. Numerous inhibitors of oxidative phosphorylation were tested for ability to release HT from mitochondria or to prevent binding. Reserpine completely depleted mitochondria of HT, but did not alter their ability to reabsorb HT, while phenyl ether and LSD partly prevented mitochondrial fixation of HT.
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