Effects of Epinephrine on Toxicities of Several Local Anesthetic Agents

Summary

With only one agent (tetracaine) of the 5 studied, was addition of epinephrine accompanied by a highly significant reduction in systemic toxicity. With the 4 remaining agents toxicity was not altered appreciably under most conditions, although procaine containing 1:50,000 epinephrine seems more toxic than procaine alone.