Abstract
Summary
1. Percentages of total and “free” amino acids in viable tissues of Sarcoma R-1 and Walker carcinosarcoma 256 grown in control and ethionine-treated male and female rats of the Wistar strain have been determined by microbiological assay methods. 2. Ethionine treatment induced no change in total amino acids but caused an increase or decrease in concentration of some “free” amino acids in viable tissue but was without marked effect on methionine. 3. It was concluded that inhibition of tumor growth by ethionine probably results largely from indirect effects on utilization of amino acids other than methionine.
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