Phosphorus Metabolism in Infection with Murine Leukemia Virus

Summary

Some aspects of phosphorus metabolism of spleens of mice infected with Friend leukemia agent have been presented. A comparison has been made of concentrations of different phosphorus-containing cellular components as well as uptake of P³² into these components. Early in the infection, before significant spleen enlargement occurs, increase in uptake of P³² is restricted to microsomal and subparticulate lipid and nucleic acid. Later when spleen enlargement is marked. all phosphorus-containing fractions studied showed increased P³² uptake. X-irradiation, which caused marked reduction in spleen size, reduced P³² uptake into fractions of both control and infected spleens, with greater reduction in the infected ones.