Chelation and Iron Metabolism I. Relative Iron Binding of Chelating Agents and Siderophilin in Serum. ∗

Summary and conclusions

1. The iron-binding ability of a series of synthetic chelating agents has been compared to that of siderophilin in rabbit serum. 2. The chelate compounds are unable to remove iron from siderophilin in rabbit serum. 3. Under the same conditions siderophilin is unable to remove iron from the more tightly bound iron chelates. 4. KDTA and HOEDTA. at iron-binding ratios of 20-25 1 and 3-5 1 respectively to that of the protein, compete on equal basis for iron added to rabbit serum.