Adaptation of Vaccinia Virus to Earle's L-Cells with Prolonged Noninfectious Period. ∗

Summary

It has been shown with a modification of the usual tissue culture technic that the Minnesota strain of vaccinia virus has been adapted to Earle's L strain fibroblasts. Following establishment of the infection, several cycles of cell growth and degeneration occurred. The adapted strain was identified by conventional cytological and serological criteria. The method described might lend itself to adaptation of other viruses.