Plasma Albumin Catabolism in Tissue Slices. ∗

Summary

I¹³¹ labeled human albumin and screened and unscreened iodinated rat and rabbit albumins were incubated with tissue slices. prepared from rat and rabbit liver, kidney, spleen, lung, heart, muscle, and skin. No breakdown was observed in rat and rabbit liver homogenate. When iodoalbumins were preinjected into animals prior to preparation of slices, to introduce iodoalbumin into the extravascular exchangeable pool of various organs, significant breakdown did not occur. Breakdown of exogenous S³⁵ biosynthetically labeled homologous albumin and globulin occurred only in slices of small intestine.