Coenzyme Q 10 and Succinate-Tetrazolium Reductase Activity of Proliferative Lesions of Liver. ∗

Conclusion

Quantitative histochemical studies of sections of normal liver, regenerating liver and Novikoff hepatoma have shown that the succinate-INT and alpha-glycerophosphate-INT reductase systems of these tissues are not saturated with respect to quinone. Compared to normal liver, degree of unsaturation is considerably greater in regenerating liver and hepatoma and largely accounts for those low reductase activities which are observed in these 2 tissues. Response of sections of regenerating liver and hepatoma to COQ₁₀ and menadione differs. COQ₁₀ is very effective in hepatoma. In regenerating liver COQ₁₀ is relatively ineffective whereas enhancement of reductase activity brought about by menadione is profound.