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Production of Incomplete Vi Antibody in Mice

Experimental Biology and Medicine

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Research article

First published online August, 1960

Production of Incomplete Vi Antibody in Mice

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Volume 104, Issue 4

https://doi.org/10.3181/00379727-104-25921

Abstract

Summary

Immunization with purified Vi antigen elicited incomplete Vi antibody in the Cinnamon strain, and complete Vi antibody in BALB/c mice. Incomplete Vi antibody alone accounted for protection afforded by serum from Cinnamon mice against challenge with fully virulent typhoid bacilli. Absorption tests verified the specificity of incomplete Vi antibody and protection it afforded.

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