Abstract
Summary
It was found that ECHO and poliomyelitis virus antisera without host CF antibodies could be prepared in guinea pigs by immunizing the animals with fluorocarbontreated cell culture grown virus. Although in repeated immunization of guinea pigs 3 out of 12 fluorocarbon-treated antigens with no host CF activity produced host antibodies in titers of 1:32 and 1:64, specific virus titers were 16 and 32 times higher. It was also found that, besides the host activity, the specific virus activity of fluorocarbon-treated antigens should be tested before using them for immunization.
The authors are indebted to Mr. Hernon Fox and Mr. Horace Turner for technical assistance.
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