Porphyrin Metabolism in Mice Following Quantitative Administration of Collidine Compounds and Oxidation Products

Conclusions

Parenteral administration of 5 mg/mouse/day of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate (“collidine derivative”) in corn oil causes increased hepatic and biliary proto- and coproporphyrin levels. Hepatic coproporphyrin was found to be entirely Type III isomer. No green porphyrins are found in livers of animals receiving “collidine derivative.” Oxidation products of “collidine derivative” did not produce abnormalities in porphyrin metabolism within a 10-day observation period.