Protective Influence of Glucose Cycloacetoacetate on Glutathione Depletion in Dietary Liver Necrosis. ∗

Summary

The influence of glucose cycloacetoacetate (GCA), its hydrolysis product and Vit. B₁₂ on depletion of blood and liver glutathione and liver ascorbic acid in rats during 35 days of feeding necrogenic diet containing 6% baker's yeast as the sole protein source, was studied. GSH level in blood and liver in animals receiving necrogenic diet was reduced to 51% and 65% of normal controls, whereas in Vit. B₁₂ injected animals corresponding values were 89% and 94% and in animals injected with hydrolyzed GCA respective values were 82% and 99%. Liver ascorbic acid of the animals fed on necrogenic diet was reduced to 63% of controls, while that in the animals injected with Vit. B₁₂ and with hydrolyzed GCA it was recorded to be 93% and 84% of controls respectively.