Abstract
Summary
In the hypophysectomized weanling rat triethylenethiophosphoramide (Thio-TEPA) produced quantitative destruction of granulosa cells and ova. Stimulation of the ovary by pituitary gonadotropin was antagonized by Thio-TEPA, resulting in blocking of luteinization and formation of cystic follicles. Diethylstilbestrol partially protected against destructive effects of Thio-TEPA on the ovary allowing luteinization to proceed. Under all circumstances Thio-TEPA caused a quantitative reduction in ovarian weight over a period of 5 days.
Get full access to this article
View all access options for this article.