Abstract
Summary
The in vitro metabolism of specifically labeled glucose by epididymal adipose tissue of mice bearing adrenocorticotropic tumors has been studied. Sluggish lipogenesis from glucose was found to be coupled with evidence suggesting decreased activity of the phosphogluconate oxidative pathway. Glyceride-glycerol synthesis was normal, and oxidation of glucose carbon in the tricarboxylic acid cycle appeared to proceed at a normal rate. Insulin added in vitro was less effective in promoting lipogenesis and glycogen synthesis than with tissue from control animals.
The authors wish to thank Dr. J. Furth, Children's Cancer Research Foundation, Boston, Mass., for providing the animals used in this study. The expert technical assistance of Miss Sylvia Chiesa and Miss Marva Hightower is gratefully acknowledged.
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