Abstract
Summary and Conclusions
It would appear from this limited study in rabbits that desmosterol lying free in extra-cellular sites is not innocuous, in that it excites an intense inflammatory reaction in the subcutaneous site of implantation. The fate of desmosterol and its distribution in the body tissues is not yet known. Whether or not desmosterol may appear freely in the extra-cellular tissues of blood vessel walls as is the case with cholesterol is also not known. Because of the fact that desmosterol does incite an intense inflammatory reaction, its fate and distribution in the body should be determined before MER-29 can be considered to be a relatively safe serum cholesterol lowering agent.
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