Abstract
Summary
1-(1-phenylcyclohexyl) piperidine · HC1 was found to be a very effective agent in suppression of audiogenic seizures in mice. It was approximately 7 times more potent than Dilantin and phenobarbital and 25 times more potent than barbital. PCP was likewise the most active anticonvulsant in electrically induced tonic extensor seizures. Like Dilantin, on the other hand, PCP was devoid of any anti-clonic seizure activity in pentylenetetrazol-induced convulsions. A comparison was also made of the anticonvulsant effects of Dilantin, phenobarbital and barbital in audiogenic, pentylenetetrazol and electrically induced convulsions.
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