Abstract
Summary
Three strains of trachoma virus and one strain of inclusion conjunctivitis virus isolated in the United States gave reproducible disease upon inoculation into eyes of rhesus or cynomolgus monkeys. Among several clinical criteria follicle scores were most suitable for quantitation of eye disease, and microscopic demonstration of inclusions in conjunctival scrapings served as additional criterion of infection. Significant differences were demonstrated in the infectivity of 2 strains for the monkey eye. Repeated eye infection failed to modify the response to re-infection. Repeated parenteral administration of live virus in large quantities significantly diminished disease from subsequent challenge infection but failed to induce solid immunity.
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