Abstract
Summary
A single intravenous dose of diethylenetriaminepentaacetate (DTPA) one hour after plutonium administration resulted in excretion of approximately 90% of the plutonium. As compared with untreated controls, retention of plutonium in the skeleton was reduced by a factor of 10 and retention in the liver was reduced by a factor of 30. Two pigs treated with 5 consecutive daily injections of DTPA excreted 11 and 19% of the plutonium injected 60 days prior to treatment.
The technical assistance of Mrs. B. Diane Chubb is gratefully acknowledged. The assistance and advice of the staff of the Experimental Animal Farm, including V. G. Horstman, M. E. Kerr, R. L. Persing, J. E. West and L. K. Bustad, were invaluable in dealing with the special problems of experimental work with swine.
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