Abstract
Summary
In short-term experiments, oxygen uptake by mouse fibroblast cells is inhibited by the addition of the convulsant Metrazol. After 30 hours of incubation in suspension culture, the effect of Metrazol is reversed. Both oxygen uptake and cell growth are enhanced. Cells grown in the presence of the drug multiply 13 times faster and use up 3 times as much oxygen as control cells.
The authors wish to express their gratitude to Dr. Warren M. Sperry without whose encouragement and support this work would not have been possible.
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